نتایج جستجو برای: ccl22

تعداد نتایج: 1448  

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2001
M C Berin M B Dwinell L Eckmann M F Kagnoff

The intestinal mucosa contains a subset of lymphocytes that produce Th2 cytokines, yet the signals responsible for the recruitment of these cells are poorly understood. Macrophage-derived chemokine (MDC/CCL22) is a recently described CC chemokine known to chemoattract the Th2 cytokine producing cells that express the receptor CCR4. The studies herein demonstrate the constitutive production of M...

Journal: :Journal of immunology 2004
John A Belperio Maria Dy Lynne Murray Marie D Burdick Ying Y Xue Robert M Strieter Michael P Keane

Increasing evidence suggests that the development of pulmonary fibrosis is a Th2-mediated process. We hypothesized that the CC chemokines that are associated with a Th2 profile (CCL17 and CCL22) have an important role in the development of pulmonary fibrosis. We measured CCL17 and CCL22 during the pathogenesis of bleomycin-induced pulmonary fibrosis. We found that both CCL17 and CCL22 were sign...

ژورنال: :مجله علمی دانشگاه علوم پزشکی بیرجند 0
سیروس نعیمی s. naeimi department of biology, science school, islamic azad university, kazerun branch, kazerun, iranکازرون- دانشگاه آزاد اسلامی واحد کازرون- بخش زیست‏شناسی تلفن: 2230505 و 07212230506 نمابر: 07212243937 نصراله عرفانی n. erfani department of immunology, shiraz institute for cancer research, medical, shiraz, iranمرکز تحقیقات سرطان، دانشگاه علوم پزشکی شیراز، ایران

زمینه و هدف: بیماری تروفوبلاستیک حاملگی یکی از عوارض دوران بارداری است که دارای زیرگروه های مختلف شامل مول کامل، مول ناقص و کوریوکارسینوما می باشد. عامل مشتق شده از ماکروفاژها یا ccl22 ، جزء خانواده کموکاین ها می باشد که توسط ماکروفاژها، سلول های دندریتیکی و سلول های توموری تولید شده و نقش مهمّی در فراخوانی لنفوسیت های t تنظیمی و لنفوسیت های t helper2 به محل تومور دارد. ژن این کموکاین دارای چندی...

Journal: :Journal of Immunology 2023

Abstract The immunoregulatory chemokine CCL22 is mainly secreted by dendritic cells (DC) in lymph nodes and plays a crucial role maintaining the balance between immune tolerance efficient response induction of intercellular contacts DC regulatory T (Treg) expressing only so far known receptor CCR4. In absence CCL22, to vaccination cancer has been proven be enhanced. this work, we aimed understa...

Ahmadi-Sina Nedaei Ahmadi Mohammad Ali Ghayumi Nasrollah Erfani, Zahra Mojtahedi

Background: An association between lung cancer and chemokines has been advocated in the recent years. This study aims at investigating the association between lung cancer and 16C/A single nucleotide polymorphism (SNP) (rs. 4359426) in C-C motif chemokine 22 (CCL22) as well as C1014T SNP (rs. 2228428) in C-C chemokine receptor type 4 (CCR4), which serves as the receptor for CCL22.Methods: Genoty...

Journal: :Journal of immunology 2008
Kunio Hieshima Daisuke Nagakubo Takashi Nakayama Aiko-Konno Shirakawa Zhe Jin Osamu Yoshie

Adult T cell leukemia is a mature CD4+ T cell malignancy which predominantly expresses CCR4 and is etiologically associated with human T cell leukemia virus type 1 (HTLV-1). Because HTLV-1 transmission depends on close cell-cell contacts, HTLV-1-infected T cells may preferentially interact with CCR4+CD4+ T cells for efficient viral transmission. In terms of gene expression and protein secretion...

2015
Chizuko Yano Hidehisa Saeki Mayumi Komine Shinji Kagami Yuichiro Tsunemi Mamitaro Ohtsuki Hidemi Nakagawa

BACKGROUND CC chemokine ligand 17 (CCL17) and CCL22 are the functional ligands for CCR4. We previously reported that inhibitors of nuclear factor-kappa B and p38 mitogen-activated protein kinase (p38 MAPK), but not of extracellular signal-related kinase (ERK), inhibited tumor necrosis factor (TNF)-α- and interferon (IFN)-γ-induced production of CCL17 by the human keratinocyte cell line, HaCaT. ...

Journal: :Proceedings of Anticancer Research 2022

Objective: To explore the mechanism by which macrophages secrete CCL22 to promote metastasis of triple-negative breast cancer under hypoxic conditions. Methods: 20 ng/mL mass concentration phorbol 12-myristate 13-acetate (PMA) cell culture medium, 4?,6-diamidino-2-phenylindole (DAPI), dimethyl sulfoxide (DMSO), trypsin digestion solution, CCL18 Kit , Interleukin (IL)-10 Kit, CCL17 TRIzolTM Reag...

Journal: :Cancer research 2015
David Anz Moritz Rapp Stephan Eiber Viktor H Koelzer Raffael Thaler Sascha Haubner Max Knott Sarah Nagel Michaela Golic Gabriela M Wiedemann Franz Bauernfeind Cornelia Wurzenberger Veit Hornung Christoph Scholz Doris Mayr Simon Rothenfusser Stefan Endres Carole Bourquin

The chemokine CCL22 is abundantly expressed in many types of cancer and is instrumental for intratumoral recruitment of regulatory T cells (Treg), an important subset of immunosuppressive and tumor-promoting lymphocytes. In this study, we offer evidence for a generalized strategy to blunt Treg activity that can limit immune escape and promote tumor rejection. Activation of innate immunity with ...

Journal: :Journal of immunology 2010
Frederic Toulza Kisato Nosaka Yuetsu Tanaka Tiziana Schioppa Frances Balkwill Graham P Taylor Charles R M Bangham

We recently reported that human T-lymphotropic virus type 1 (HTLV-1) infection is accompanied by a high frequency of CD4(+)FoxP3(+) cells in the circulation. In asymptomatic carriers of HTLV-1 and in patients with HTLV-1-associated inflammatory and malignant diseases, a high FoxP3(+) cell frequency correlated with inefficient cytotoxic T cell-mediated killing of HTLV-1-infected cells. In adult ...

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