Methods The data on 2271 patients was investigated in a cross-sectional study. All patients at the moment of survey had no attributes of clinical progression of disease and did not receive HAART. Clinical exam and blood sampling was performed, in blood specimens HIV virus load (PCR m2000rt Abbott Biosystems analyzer, RealTime HIV-1 sets) and CD3+CD4+ and CD3+CD4phenotypes of T-lymphocytes were ...

and Cancer Research Laboratory ment, wherein cells destined to develop into ab T cells Division of Immunology must express a functional TCRb chain in order to effiUniversity of California at Berkeley ciently proceed to the CD252CD442 stage (Mombaerts Berkeley, California 94720 et al., 1992a; Shinkai et al., 1993; Dudley et al., 1994; †Basel Institute for Immunology Fehling et al., 1995). The su...

Many signals that cause apoptotic cell death operate by inducing transcription and translation of other (presumably death effector) mediators, and it is well established that stimulus-induced apoptosis can often be blocked by inhibiting transcription and translation. Transcriptional regulation of apoptosis, however, is incompletely understood. To gain insight into nuclear events associated with...

BACKGROUND Double positive (DP) CD4CD8 Talphabeta cells have been reported in normal individuals as well as in different pathological conditions including inflammatory diseases, viral infections and cancer, but their function remains to be elucidated. We recently reported the increased frequency of DP Talphabeta cells in human breast pleural effusions. This manuscript addresses the question of ...

Author contributions: I.M performed most of the research, analyzed data and co-wrote the paper. R.A.G performed some experiments and analyzed data. L.N contributed to the design of the study and supervised experimental work. A.C designed and performed the statistical analysis of the cytogenetics data. C.J.G and J.S.D designed the study, supervised the experimental work and co-wrote the manuscript.