the two stable isotopes of hydrogen, protium (1h) and deuterium (2h) differ in their physicochemical nature. deuterium-depleted water (ddw) significantly inhibited the growth rate of different tumor cell lines in culture media and xenotransplanted mda-mb-231, mcf-7 human breast adenocarcinomas and pc-3 human prostate tumors in vivo. the apoptosis-triggering effect of ddw was demonstrated both i...

background and objective: microbial protein production can resolve one of the major world challenges, i.e. lack of protein sources. candida tropicalis growth was investigated to specify a medium to reach the highest cell proliferation and protein production. material and methods: fractional factorial design and the index of signal to noise ratio were applied for optimization of microbial protei...

background: in this study, we evaluated the protective effects of water hyacinth root powder (hrp) on arsenic-mediated toxic effects in mice. methods: swiss albino mice, used in this study, were divided into four different groups (for each group n=5). the control group was supplied with normal feed and water, arsenic group (as-group) was supplied with normal feed plus arsenic (sodium arsenite)-...

there is an impression that basal cell carcinomas (bcc) occurring in younger population may be of more invasive behavior in comparison to those arising in older patients. the purpose of this study was to investigate this hypothesis by comparing the histological types of bcc in a large cohort of young and old patients. a total of 287 histological reports and clinical records were evaluated. a co...

ovarian cancer is one of the major causes of death in women. parabens are a class of chemicals widely used as preservatives in cosmetic and pharmaceutical products, they mimic estrogens, which are known to play a role in the development of different cancers in women. the aim of this study was to investigate the proliferative effects of methyl paraben (mp) and propyl paraben (pp) on human ovaria...

hyaline cartilage is a vascular and neural tissue with scanty chondrocytes and limited regenerative ability. after some serious injuries of the cartilage, healing process will take place through the formation of fibrocartilage structures. currently, tissue engineering and cell therapy are 2 interesting therapeutic fields dealing with regenerative medicine. in this regard, tissue regeneration ha...

Light is an effective factor in cell suspension culture and must be controlled for optimizing cell growth. Growth of anthocyanin producing suspension cells of a red-fleshed genotype of apple (RFA) was assessed in response to blue diode laser (BDL) and red He Ne (RHNL) laser. The suspension cells in L-shaped test tubes were exposed to short-term laser radiation for 20 min in a rotary shaker. The...

background: the current study investigated the possible role of the cell cycle regulator, cyclin-dependent kinases regulatory subunit-2; the angiogenic factor, plateletderived endothelial cell growth factor; and the cell adhesive molecule, neural cadherin, as prognostic factors in schistosomal and non-schistosomal-associated urothelial carcinomas. we also investigated the possible correlation b...