Canonical Wnt signalling plays an important role in development, tissue homeostasis, and cancer. At the cellular level, canonical Wnt signalling acts by regulating cell fate, cell growth, and cell proliferation. With regard to proliferation, there is increasing evidence for a complex interaction between canonical Wnt signalling and the cell cycle. Mitogenic Wnt signalling regulates cell prolife...

Polyphosphoinositides (PPIns) are signalling messengers representing less than five per cent of the total phospholipid concentration within cell. Despite their low concentration, these lipids critical regulators various cellular processes, including cell cycle, differentiation, gene transcription, apoptosis and motility. PPIns generated by phosphorylation inositol head group phosphatidylinosito...