According to the WHO’s recently released worldwide cancer data for 2020, liver ranks sixth in morbidity and third mortality among all malignancies. Hepatocellular carcinoma (HCC), most common kind of cancer, accounts approximately 80% primary malignancies is one leading causes death globally. The intractable tumor microenvironment plays an important role development progression HCC three major ...

While a significant number of studies have focused on elucidating the functioning mechanisms Hepatocellular carcinoma (HCC) microenvironment, intercellular crosstalk between multiple cells in tumor microenvironment remains unclear. Here we co-cultured spheroids HCC cells, hepatic stellate (HSCs), and hepatocytes biomimetic composite hydrogel to construct 3D model vitro. The reproduced major cel...

This mini-review discusses agent-based models as modeling techniques for studying pattern formation of multi-cellular systems in biology. We introduce and compare different model frameworks with respect to spatial representation, microenvironment, intracellular extracellular reactions, cellular properties, implementation, practical use. The guiding criteria the considered selection are that the...