نتایج جستجو برای: cellular reprogramming

تعداد نتایج: 449138  

2012
Byeong-Moo Kim Marc-Christian Thier Sangnam Oh Richard Sherwood Chryssa Kanellopoulou Frank Edenhofer Michael Y. Choi

MicroRNAs play a pivotal role in cellular maintenance, proliferation, and differentiation. They have also been implicated to play a key role in disease pathogenesis, and more recently, cellular reprogramming. Certain microRNA clusters can enhance or even directly induce reprogramming, while repressing key proteins involved in microRNA processing decreases reprogramming efficiency. Although micr...

Journal: :International Journal of Molecular Sciences 2020

Journal: :Seminars in Cancer Biology 2015

Journal: :Current Opinion in Genetics & Development 2014

Journal: :international journal of pediatrics 0
hoda mollaei department of biology, faculty of natural sciences, university of tabriz, tabriz, iran. mohammad khalaj-kondori department of biology, faculty of natural sciences, university of tabriz, tabriz, iran.

the use of animal models in modeling of human genetic disease has many advantages. in some cases, however, this method may not be applicable due to some limitations, such as differences in tissue composition, anatomy and physiology of humans and animals. isogenic human disease models are a population of cells that are selected or engineered to model a specific genetic disease, in vitro. they ar...

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