نتایج جستجو برای: cellular senescence
تعداد نتایج: 453587 فیلتر نتایج به سال:
Senescence is an irreversible cell-cycle arrest process induced by environmental, genetic, and epigenetic factors. An accumulation of senescent cells in bone results age-related disorders, one the common problems osteoporosis. Deciphering basic mechanisms contributing to chronic ailments aging may uncover new avenues for targeted treatment. This review focuses on most relevant research advancem...
Chronic obesity leads to inflammation, tissue dysfunction, and cellular senescence. It was proposed that cellular senescence during obesity and aging drives inflammation and dysfunction. Consistent with this, clearance of senescent cells increases healthspan in progeroid mice. Here, we show that the protein Deleted in Breast Cancer-1 (DBC1) regulates cellular senescence during obesity. Deletion...
Senescence occurs as a part of the cellular response to different stressors. With increasing age, continuous exposure stressors leads age-induced senescence. Pancreatic ?-cell proliferation and glucose homeostasis also decrease with which results in ? cell mass and, eventually, possible development diabetes. This process is mediated through impaired cycle regulators, along specific increases in...
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