Leydig cell testicular tumors are a rare cause of precocious pseudopuberty in boys. Surgery is the main therapy and shows good overall prognosis. The physical signs of precocious puberty are expected to disappear shortly after surgical removal of the mass. We report two children, 7.5 and 7.7 year-old boys, who underwent testis-sparing surgery for a Leydig cell testicular tumor causing precociou...

The Committee of Central Precocious Puberty Korean Pediatrics and Adolescents the Society Pediatric Endocrinology has newly developed evidence-based 2022 clinical practice guidelines for central precocious puberty in children adolescents. These provide grade recommendations, which includes both strength recommendations level evidence. In absence sufficient evidence, are based on expert opinion....

Growth in precocious puberty is a subject of concern to families and clinicians alike. The definition of precocious puberty and the role of obesity in the age of onset have also been areas of debate since the Lawson Wilkins Society recommended a lowering of the age of onset of precocious puberty in US girls. An understanding of growth patterns in normal children with earlier or later onset of p...

Appearance of secondary sexual characteristics before 9 years of age in boys constitutes precocious puberty(l). There are three major types of sexual precocity: true or central, peripheral and combined peripheral and central. Precocious puberty may be isosexual or heterosexual in nature. In this communication we report a case of meningomyelocele who developed isosexual precocious puberty second...

INTRODUCTION Changes in body mass index (BMI) among girls with idiopathic central precocious puberty (ICPP) under treatment have been controversial in other populations. OBJECTIVE To assess changes in BMI Z score and the rate of overweight and obesity in Mexican girls with ICPP during their first year of treatment. METHODOLOGY A retrospective study was conducted among girls with ICPP under ...

Central precocious puberty (CPP) is characterized by the same biochemical and physical features as normally timed puberty but occurs at an abnormally early age. Most cases of CPP are seen in girls, in whom it is usually idiopathic. In contrast, ~50% of boys with CPP have an identifiable cause. The diagnosis of CPP relies on clinical, biochemical, and radiographic features. Untreated, CPP has th...

BACKGROUND There are no absolute criteria for identifying those girls with idiopathic central precocious puberty (CPP) who will benefit from gonadotropin-releasing hormone analog (GnRHa) treatment. Our objective was to predict at initial evaluation the differences between adult height (AH) and target height (TH) and (for untreated girls) the time between puberty onset and first menstruation. ...

We present a five year old boy with central precocious puberty and pineal gland cyst on neuroimaging. This association is uncommon and highlights the role of pineal gland in puberty.

PURPOSE The progressivity of central precocious puberty (CPP) seems to depend on the age at presentation. We evaluated the clinical courses of CPP girls according to their age at initiation of treatment. METHODS One hundred thirty five girls with CPP diagnosed between Jan. 2003 and Dec. 2009 and regularly followed for more than one year were included. They were treated with gonadotropin-relea...

OBJECTIVE Gonadotropin stimulation test is the gold standard to document precocious puberty. However, the test is costly, time-consuming and uncomfortable. The aim of this study was to simplify the intravenous gonadotropin-releasing hormone (GnRH) stimulation test in the diagnosis of precocious puberty and in the assessment of pubertal suppression. METHODS Data pertaining to 584 GnRH stimulat...