BACKGROUND AND PURPOSE Cerebral amyloid angiopathy is a small to medium vasculopathy most commonly associated with symptomatic intracerebral hemorrhage and microbleeds. Summary of Case- We present a patient with cerebral microbleeds and likely amyloid angiopathy with evolving ischemic lesions visualized on diffusion-weighted imaging. CONCLUSIONS This case captures with serial MRI the evolving...

BACKGROUND AND PURPOSE Cerebral amyloid angiopathy Type 1 is characterized by amyloid β protein deposition along cerebral capillaries and is accompanied by perivascular neuroinflammation and accumulation of phospho-tau protein. Tg-SwDI mice recapitulate capillary amyloid deposition and associated neuroinflammation but lack accumulation of perivascular phospho-tau protein. METHODS Tg-SwDI mice...

Background and Purpose—Cerebral amyloid angiopathy Type 1 is characterized by amyloid protein deposition along cerebral capillaries and is accompanied by perivascular neuroinflammation and accumulation of phospho-tau protein. Tg-SwDI mice recapitulate capillary amyloid deposition and associated neuroinflammation but lack accumulation of perivascular phospho-tau protein. Methods—Tg-SwDI mice wer...

To cite: Datta S, Ramadan H, Werring DJ. Pract Neurol 2015;15:74–75. SUMMARY MRI-visible perivascular spaces are a recently recognised neuroimaging marker of cerebral small vessel diseases and centrum semiovale MRI-visible perivascular spaces may be a neuroimaging marker of cerebral amyloid angiopathy. We report an elderly woman with speech and memory disturbance, whose MR scan of brain showed ...

Prominent cerebral amyloid angiopathy is often observed in the brains of elderly individuals and is almost universally found in patients with Alzheimer's disease. Cerebral amyloid angiopathy is characterized by accumulation of the shorter amyloid-β isoform(s) (predominantly amyloid-β40) in the walls of leptomeningeal and cortical arterioles and is likely a contributory factor to vascular dysfun...

Prominent cerebral amyloid angiopathy is often observed in the brains of elderly individuals and is almost universally found in patients with Alzheimer’s disease. Cerebral amyloid angiopathy is characterized by accumulation of the shorter amyloid-b isoform(s) (predominantly amyloid-b40) in the walls of leptomeningeal and cortical arterioles and is likely a contributory factor to vascular dysfun...

Background: Intracerebral hemorrhage is a complication of thrombolytic therapy in stroke patients. Furthermore, Cerebral Amyloid Angiopathy (CAA), which itself can cause hemorrhage, may be risk factor for thrombolysis related intracerebral hemorrhage.

This report discusses a case of nonconvulsive status epilepticus, caused by cerebral amyloid angiopathy-related inflammation. Brain biopsy demonstrated cerebral amyloid angiopathy, with clinical and radiographic features indicative of a fluctuating inflammatory process. Immunomodulatory treatment with pulse steroids resulted in rapid and dramatic clinical and radiographic improvement. Cerebral ...

Cerebral amyloid angiopathy can present as lobar intracerebral hemorrhage in an elderly person, presumably due to increased fragility of the vessels affected by amyloid deposition. For this reason, patients presenting with intracerebral hemorrhage and suspected of having cerebral amyloid angiopathy have often been treated nonsurgically. Since 1983 we have evaluated 11 patients with cerebral amy...