Mucosal tolerance is a naturally occurring immunological phenomenon that prevents harmful inflammatory responses to ingested or inhaled environmental, predominantly nondangerous, Ags. The nasal mucosa is an extremely efficient compartment in the induction of immunological tolerance which can be exploited in Ag-specific treatment of autoimmune disease. With the use of a model Ag (OVA) and an Ag ...

BACKGROUND To evaluate the prevalence of human papilloma virus (HPV) infection and types in the oral and cervix mucosa of treatment-naïve HIV-1-positive women with CD4 counts less than 300 cells per ml with no HPV-associated oral lesions. METHODS Oral epithelium was harvested from the buccal mucosa and lateral borders of the tongue and cervical samples were collected from the endocervical are...

Cervical lesions can be caused by pathogens, hormonal changes or cervical injury. The recommended treatment in all cases is excision. Local re‑epithelialization therapy should initiated preoperatively and postoperatively. present study assessed the post‑market performance tolerability of Cerviron® ovules management population included 345 participants aged 20‑70 years with either a l...

The aim of this study was to reveal whether 3 biomarkers (p16INK4a, ProEx C, and human papilloma virus DNA) are useful in the diagnosis of cervical intraepithelial neoplasia and whether they could predict disease progression of cervical intraepithelial neoplasia-1. We analyzed 252 cervical specimens: nondysplastic mucosa (n = 9), cervical intraepithelial neoplasia (n = 229), and squamous cell c...

Progranulin (PGRN) is an autocrine growth factor with tumorigenic roles in various tumors including cervical cancer. In this study, we investigated mammalian target of rapamycin (mTOR) signaling in response to PGRN induction and the contribution of the PGRN-stimulated PI3K/Akt/mTOR signaling pathway in the transformation and progression of cervical cancer. Here we identified a strong linkage be...

Abstract Background and Objectives Transcutaneous point-of-care ultrasound (POCUS) is a good tool to monitor the trachea in many clinical practices. The aim of our study verify feasibility POCUS-guided submucosal injection as potential drug delivery method for treatment tracheal stenosis. Materials methods inner wall was monitored via bronchoscope during methylene blue fresh ex vivo porcine eva...

Vulvovaginal Candidiasis (VVC) is a fungal infection caused by Candida spp. of the genital mucosa that still health concern for women.This first-of-its-kind investigation on isolation dubliniensis, from cervical-vulvovaginal patients in Erbil hospitals. The study was carried out and identification which performed using phenotypic molecular approaches. A total one hundred samples vaginal swabs (...

Stratified squamous epithelia of oral and cervical mucosa express high levels of simple mucin-type O-linked carbohydrates, and these are known to undergo structural changes in relation to epithelial differentiation and neoplastic transformation. O-glycans in these epithelia are associated with the cell membrane, but the identity of the carrier molecule(s) remains largely unknown. We report here...

The aim of this study to determine the depth of tumor invasion and pattern of cervical metastasis in patients of OSCC with OSMF. Methods: The authors prospectively investigated 40 patients of OSCC with OSMF who underwent surgery for OSCC with curative intent over a 2 year period. OSCC with OSMF was more commonly seen in males (87.5%) compared to females (12.5%). Buccal mucosa was the most frequ...