نتایج جستجو برای: cervix dysplasia
تعداد نتایج: 49987 فیلتر نتایج به سال:
BACKGROUND To investigate the implication of ribonucleotide reductase M2 (RRM2) in the carcinogenesis of uterine cervix and its relationship with clinicopathological characteristics and prognosis of cancer patients. METHODOLOGY AND PRINCIPAL FINDINGS The impact of RRM2 on cell viability was investigated in SiHa cervical cancer cells after RRM2 knockdown and the addition of cisplatin, which in...
Progressive accumulation of DNA lesions leads to genetic mutations that are central to the process of tumorigenesis. Human cervix provides an ideal system to determine progressive accumulation of DNA adducts in the target tissue because of its accessibility during routine diagnostic checkups. Uterine cervix samples from various pathologies, i.e. normal (n=13), inflammation (n=9), dysplasia (n=5...
BACKGROUND Cell regulatory G2/M phase proteins are the key regulators of mitosis and have been reported with abnormal expressions in various malignancies. AIM To determine the expressions of these proteins in neoplastic uterine cervix tissue. MATERIALS AND METHODS This study evaluates the G2/M phase regulatory protein expression of Cyclin B1, Aurora-B, Pololike kinase 1 (PLK1) and LIM kinas...
Detection of Human Papillomavirus DNA in Invasive Carcinomas of the Cervix by in Situ Hybridization1
An examination of 27 invasive cancers of the cervix was performed using the technique of in situ hybridization using human papillomavirus DNA probes. Four tissues, previously found to harbor papillomavirus DNA by filter hybridization, were confirmed by in situ analysis. One further tissue never previously studied was also found to be positive by in situ hybridization. Overall, we found 33% of i...
Detection of human papillomavirus DNA in invasive carcinomas of the cervix by in situ hybridization.
An examination of 27 invasive cancers of the cervix was performed using the technique of in situ hybridization using human papillomavirus DNA probes. Four tissues, previously found to harbor papillomavirus DNA by filter hybridization, were confirmed by in situ analysis. One further tissue never previously studied was also found to be positive by in situ hybridization. Overall, we found 33% of i...
1. Cash R, Wikler D, Saxena A, Capron A, editors. Casebook on ethical issues in international health research. Geneva: World Health Organisation 2009;124-5. 2 Richart RM. Natural history of cervical intraepithelial neoplasia. Clin Obstet Gynecol. 1968:10:748-84. 3. Coppleson M. The value of colposcopy in the detection of preclinical carcinoma of the cervix (Three years’ experience at King Georg...
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