BACKGROUND The aim of our study was to investigate effects of 6-week pretreatment of seasonal allergic rhinitis (AR) with cetirizine, and montelukast, alone and in combination. Antihistamine/antileukotriene treatment is effective in AR. Antihistamines may prevent AR symptoms while prophylactic activity of antileukotrienes remains unclear. METHODS Sixty AR patients, aged 18-35 years, were rand...

OBJECTIVES To compare the efficacy and tolerability of butterbur (Petasites hybridus) with cetirizine in patients with seasonal allergic rhinitis (hay fever). DESIGN Randomised, double blind, parallel group comparison. SETTING Four outpatient general medicine and allergy clinics in Switzerland and Germany. PARTICIPANTS 131 patients were screened for seasonal allergic rhinitis and 125 pati...

The kinetics and mechanism of oxidation of cetirizine hydrochloride by Mn(VII) in acidic medium was studied spectrophotometrically. The electron transfer reaction between MnO4 and the drug have been studied over the range 2.0 ≤ 10 [cetirizine hydrochloride] ≤ 6.0, 2.5 ≤ pH ≤ 4.5 and 295 K ≤ T ≤ 313 K in aqueous medium. The electron transfer reaction shows first order dependence in [MnO4 ] T and...

BACKGROUND AND OBJECTIVES Histamine receptors mediate nociceptive pathways, especially in the central nervous system. Some studies have demonstrated the analgesic effects of histamine receptor antagonists in the peripheral nervous system. It is not clear whether the local analgesic effect is class-specific or drug-specific. METHODS To answer this question, we used three different H1 receptor ...

A 21‐year‐old male patient presented to department of dermatology with chief complaints of itchy dark‐colored lesion over his left lower leg since 2 months. On examination there was single localized, scaly, hyperpigmented, and eczematous plaque. Diagnosis of nummular eczema was made and patient was advised topical steroid with emollients and oral cetirizine 10 mg per day to control pruritus. Th...

The effect of cetirizine on plasma membrane fluidity and heterogeneity of human eosinophils, neutrophils, platelets and lymphocytes was investigated using a fluorescence technique. Membrane fluidity and heterogeneity were studied by measuring the steady-state fluorescence anisotropy and fluorescence decay of 1-(4- trimethylammonium-phenyl)-6-phenyl-1, 3, 5-hexatriene (TMA-DPH) incorporated in t...

The chemical name of cetirizine hydrochloride is (±)-2-[2-[4-(4-chlorophenyl) phenylmethyl]-1-piperazinyl] ethoxy acetic acid dihydrochloride (C21H25ClN2O3•2HCl). Cetirizine hydrochloride is an antihistamine with selective antagonism to H1 receptors. Characterized by rapid onset, long duration of action and good safety, it is now a clinical medicine of autonomous production commonly used in Chi...

Drug-induced dystonic reactions are a common presentation to the Pediatric Emergency Department frequently with antiemetics, antidepressants, dopamineblocking agents and antipyschotics. We report a case of generalized form of dystonia after taking albendazole and cetirizine. There is only one case with albendazole induced and two cases with cetirizine induced dystonia in the literature.

Purpose: To assess the suitability of beagle dog as an animal model for the evaluation of formulations in bioavailability and bioequivalence studies. Methods: A generic cetirizine 10 mg tablet formulation was compared with another reference formulation using beagle dog as animal model. A crossover oral comparative bioavailability study was conducted on cetirizine tablet 10 mg in healthy, male d...

BACKGROUND Flu-like syndrome (FLS) is a common adverse event experienced by patients with relapsing-remitting multiple sclerosis (RRMS) treated with interferon beta (IFNβ). FLS can lead to poor treatment adherence and early IFNβ discontinuation. The involvement of interleukin-6 (IL-6) in the occurrence of FLS has been suggested. We hypothesized that cetirizine, a second-generation histamine H1 ...