introduction: considering the long traditional history of anti-inflammatory and anti-spasmodic effects of matricria spices on the gastrointestinal system, the present study aimed to investigate the role of calcium channels and histamine receptors in the inhibitory effects of hydroalcoholic dry extract of german chamomile (matricaria recutita l.) on the isolated rabbit jejunum. methods: all expe...

Infusion reactions are serious complications associated with modern antibody therapy. In order to reduce the incidence and severity of such reactions, the newer generations of monoclonal antibodies contain less or no mouse-specific protein sequences. We describe the clinical course of a patient who experienced an infusion reaction following the administration of the chimeric epidermal growth fa...

The purpose of the present study was to comparatively evaluate the effect of newer antihistamines on psychomotor functions in Indian population. Seventy five patient volunteers were included in the study. Volunteers were put into 5 groups based on the type of antihistamine prescribed. Group-1 volunteers included those who were prescribed no antihistamine, group-2 were prescribed first generatio...

Several antihistaminics possess antibacterial activity against a broad spectrum of bacteria. However, the exact mechanism of such activity was unclear. Hence, the aim of this study is to investigate their mechanism of antibacterial activity especially their effect upon the permeability of the bacterial cytoplasmic membrane. The effects of azelastine, cetirizine, cyproheptadine and diphenhydrami...

PURPOSE P-glycoprotein (P-gp) plays a major role in oral absorption of drugs. Induction or inhibition of P-gp by drugs contributes to variability of its transport activity and often results in clinically relevant drug-drug interactions. The purpose of this study was to investigate the effect of cetirizine, a second generation H1 antihistamine, on P-gp function and expression in vitro and in sit...

BACKGROUND The process of drug discovery and development today encompass a myriad of paths for bringing a new therapeutic molecule that has minimal adverse effects and of optimal use to the patient. Chirality was proposed in the direction of providing a purer and safer form of drug [Ex- cetrizine and levocetrizine]. Decades have passed since the introduction of this concept and numerous chiral ...

One of the common side effects of antihistamine medicines is xerostomia (dry mouth). The current consensus is that antihistamine-induced xerostomia comes from an antimuscarinic effect. Although the effect of antihistamines on salivary secretion is both obvious and significant, the cellular mechanism whereby this happens is still unclear because of the lack of knowledge of histamine signaling in...

BACKGROUND Recent studies on prescribing among outpatients in hospitals in Western Nepal are lacking. The main objectives of the study were to obtain information on the morbidity pattern among outpatients and to analyze prescribing using drug use indicators. METHODS A retrospective hospital record based study from 01.01.2004 to 31.12.2004 was carried out among individuals attending the outpat...

In general practice many of the patients come with a problem of allergic rhinitis and having history of taking medicines like levocetrizine or cetrizine with or without use nasal steroidal spray but the problem persists since several years with little or no improvements. As per my clinical practice I used some new approach with the conventional prescriptions on more than 50 patients who are hav...

A 24 yrs old unmarried chronic alcoholic male, compounder by occupation was admitted with multiple patchy discolouration of skin and swelling all over the body for 2 months and sudden onset altered sensorium for one day. History of self medication in the form of intravenous injection of dexamethasone for last 11⁄2 years was also present. History of sexual contact was not available. History of f...