نتایج جستجو برای: cgrp
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مقدمه: پپتید مرتبط به ژن کلسیتونین (CGRP) یک نوروپپتید 37 اسید آمینهای است که توسط فرایند ویژهی بافتی از ژن کلسیتونین تولید میشود و تولید عمدهی آن در بافتهای اعصاب مرکزی و محیطی گونههای مهرهداران و غیرمهرهداران است. CGRP در سازگاریهای پیوندگاه عصبی ـ عضلانی نقش مهمی دارد. در این پژوهش اثر تمرینهای استقامتی و مقاومتی بر میزان CGRP در عضلات تند انقباض (درشت نی قدامی) و کند انقباض ...
Calcitonin gene-related peptide (CGRP) receptors are classified into CGRP subtype 1 (CGRP(1)) and CGRP subtype 2 (CGRP(2)) based on the affinity of the antagonist, human alpha (halpha)-CGRP(8-37). halpha-CGRP(8-37) antagonizes CGRP(1) receptor-mediated responses with high affinity (K(B) < 100 nM) and antagonizes CGRP(2) receptor-mediated responses with low affinity (K(B) > 1 microM). CGRP(2) re...
The calcitonin gene-related peptide (CGRP) has been demonstrated relating to vascular and inflammatory regulations not only the nerve systems. As anti-inflammation factor most potent vasodilator, CGRP holds therapeutic potentials for treatment of cardiovascular diseases which was, however, limited by its nature short half-life. With advantages in improving stability, circulation time protection...
objective(s) recent studies on human indicate that the introduction of therapeutic use of tolerogenic dendritic cell (dc) for chronic inflammatory conditions is imminent. for the purpose of defining cgrp potency in tolerogenic dc production, we investigated the phenotype and il-'2 production of dcs generated from the monocytes of rheumatoid arthritis (ra) patients in the presence of the ca...
هدف از این مطالعه تعیین تاثیر تخلیه گلیکوژنی بر پاسخ cgrp در حین تمرین استقامتی و اثر احتمالی لاکتات بر آزاد سازی آن در شرایط استراحت بود. 10 نفر دانشجوی مرد فعال تربیت بدنی با میانگین سن 67/1±4/22، وزن 56/5 ± 28/71 و شاخص توده بدنی 07/1 ± 31/23 به صورت هدفمند انتخاب و در 4 وهله مجزا با حداقل فاصله زمانی یک هفته 4 آزمون جهت سنجش pmax، انجام فعالیت استقامتی حاد پس از تخلیه گلیکوژن (کوشش تخلیه)، ...
It is known that the neural system plays a fundamental role in neovascularization. A neuropeptide, calcitonin gene-related peptide (CGRP), is widely distributed in the central and peripheral neuronal systems. However, it remains to be elucidated the role of CGRP in angiogenesis during ischemia. The present study examined whether endogenous CGRP released from neuronal systems facilitates revascu...
Calcitonin-gene-related peptide (CGRP) is a 37-amino-acid vasodilatory peptide, of which two isoforms, alpha CGRP and beta CGRP, have been described. The use of C-terminal fragments of CGRP peptide, such as human alpha CGRP-(8-37), has led to the pharmacological subdivision of CGRP receptors into CGRP-1 [high potency for binding of human alpha CGRP-(8-37)] and CGRP-2 (lower potency) receptors. ...
Historically, calcitonin gene-related peptide (CGRP) receptors have been divided into two classes, CGRP(1) and CGRP(2). After the cloning of calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs), it became clear that the CGRP(1) receptor was a complex between CLR and RAMP1. It is now apparent that the CGRP(2) receptor phenotype is the result of CGRP acting at ...
Previous studies have demonstrated positive-inotropic effects of calcitonin gene-related peptide (CGRP), but the mechanisms remain unclear. Therefore, two experiments were performed to determine the physiological correlates of the positive-inotropic effects of CGRP. Treatments designed to antagonize the effects of physiologically active CGRP₁₋₃₇ included posttreatment with CGRP₈₋₃₇ and pretreat...
Calcitonin gene-related peptide (CGRP; official name CALCA) has a variety of functions and exhibits both angiogenic and anti-inflammatory properties. We previously reported the angiogenic effects of the CGRP family peptide adrenomedullin in oxygen-induced retinopathy; however, the effects of CGRP on ocular angiogenesis remain unknown. Herein, we used CGRP knockout (CGRP(-/-)) mice to investigat...
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