Release of acetylcholine (ACh) in the hippocampus (HC) occurs during exploration, arousal, and learning. Although the medial septum-diagonal band of Broca (MS-DBB) is the major extrinsic source of cholinergic input to the HC, cholinergic neurons intrinsic to the HC also exist but remain poorly understood. Here, ChAT-tauGFP and ChAT-CRE/Rosa26YFP (ChAT-Rosa) mice were examined in HC. The HC of C...

Online text chat is a very popular Internet-based application. Previous studies have identified several problems with standard text chat systems. Real-time collaborative editing systems can be used for text chat. This paper compares text chat via collaborative editing systems with text chat via standard text chat systems. It has been identified that standard text chat system do not maintain som...

early screening of autism increases the chance of receiving timely intervention. using the parent report questionnaires is effective in screening autism. the q-chat is a new instrument that has shown several advantages than other screening tools. because there is no adequate tool for the early screening of autistic traits in iranian children, we aimed to investigate the adequacy of the persian ...

Chat (Cas/HEF1-associated signal transducer) is a novel signaling molecule with an N-terminal SH2 domain and C-terminal Cas/HEF1 association domain that is implicated in the regulation of cell adhesion. The Cas/HEF1 association domain also shows sequence similarity with guanine nucleotide exchange factors for Ras family small GTPases. In this study, we found significant activation of Rap1 in Ch...

Background: Myenteric interneurones are involved in the reflexes that control the motility of the human colon. Aims: The distribution of choline acetyltransferase (ChAT) and nitric oxide synthase (NOS) immunoreactivity in myenteric interneurones was investigated in this study. Methods: DiI (1,1′didodecyl 3,3,3′,3′-indocarbocyanine perchlorate) was applied to the myenteric plexus of the human co...

The M-transcript of human choline acetyltransferase (ChAT) produces an 82-kDa protein (82-kDa ChAT) that concentrates in nuclei of cholinergic neurons. We assessed the effects of acute exposure to oligomeric amyloid-β1-42 (Aβ1-42) on 82-kDa ChAT disposition in SH-SY5Y neural cells, finding that acute exposure to Aβ1-42 results in increased association of 82-kDa ChAT with chromatin and formation...