introduction: atherosclerosis, hypertension, ischemic diseases, alzheimer’s disease, parkinson disease, cancer and inflammation emerge from imbalance between antioxidant and oxidants. cancer is a most important public health problem in both developed and developing countries. natural antioxidants such as polyphenols are being used for prevention and treatment cancer. polyphenols include phenoli...

Effects of some polyphenols and their related compounds (chlorogenic acid, caffeic acid, quinic acid, ferulic acid, gallic acid, D-(+)-catechin, D-(-)-catechin, 4-hydroxy-3-methoxybenzoic acid, salicylic acid, L-dopa, dopamine, L-adrenaline, L-noradrenaline, o-dihydroxybenzene, m-dihydroxybenzene, and p-dihydroxybenzene) on the formation of 13-hydroperoxide octadecadienoic (13-HPODE) acid-deriv...

Regular packed cell transfusion in patients with thalassemia major leads to iron overload. Chelation therapy is one of the important aspects of thalassemia care as iron overload causes significant cardiac, hepatic, and endocrine dysfunction. We report a case of thalassemia major with severe iron overload causing cardiac and liver dysfunction who benefitted from triple drug chelation therapy. Tr...

The application of organic electrode materials can make the whole cycle lithium battery operation effective for green sustainability. However, poor electronic conductivity and strong solubility in nonprotonic electrolytes limit anodes. Here, a novel anode material, TP-Ni, was fabricated through simple chelation tea polyphenols with nickel ions. Benefiting from coordination bonds that alter intr...

There is persuasive epidemiological evidence that regular intake of dietary bioactive polyphenolic compounds promotes human health. Because dietary polyphenolic compounds have a wide range of effects in vivo and vitro, including chelation of metals such as iron, it is prudent to test whether the regular consumption of bioactive polyphenolic components impair the utilization of dietary iron. We ...

The aim of the present work was to investigate the chemical composition, mineral extractability, and antioxidant capacity of six date palm varieties grown in Sudan. The results showed that Sudanese date varieties contained significantly different (P < 0.05) amounts of moisture, ash, fiber, oil, and carbohydrates, but have almost similar amounts of protein. Moreover, results revealed that date v...

As the population ages, neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD) impose a heavy burden on society and families. The pathogeneses of PD and AD are complex. There are no radical cures for the diseases, and existing therapeutic agents for PD and AD have diverse side effects. Tea contains many bioactive components such as polyphenols, theanine, caffei...

The linear models for the calculation of pIC50, pKa1 and Epa for 12 polyphenolic compounds (catechins, flavonols, catechol and gallol derivatives) were developed. As descriptors we used the number of vicinal (Nv) and non-vicinal (Nnv) OH groups, as well as the number of OH vicinal pairs as possible Fe2+ chelate sites (Nch). The models gave r ˃ 0.9 and standard errors of 0.13, 0.26 and 0.04 for ...

Balancing systemic iron levels within narrow limits is critical for maintaining human health. There are no known pathways to eliminate excess iron from the body and therefore iron homeostasis is maintained by modifying dietary absorption so that it matches daily obligatory losses. Several dietary factors can modify iron absorption. Polyphenols are plentiful in human diet and many compounds, inc...

Wastes generated from the processing of some fruits still contain large amounts of chemical components such as polyphenols, which are deemed as very effective antioxidants.This study involves the characterization of wastes generation by pink guava processing and selection of the best solvent that will allow us to extract the excess polyphenols via ultra-filtration membran...