thalassemia is the most prevalent genetic disorder in iran and around the world and these patients need regular careful care. the present study reports results of routine examination of patients visited thalassemia clinic of tehran. data about clinical and laboratory examinations of 413 thalassemic were extracted and analyzed. the prevalence of heart complications, diabetes, growth retardation,...

On a sequence of soils developed under similar vegetation, temperature and precipitation conditions, but with variations in mineralogical properties, we use organic carbon and C inventories to examine mineral protection of soil organic carbon. In these soils, C data indicates that the creation of slow-cycling carbon can be modeled as occurring through reaction of organic ligands with Al and Fe ...

The biosorption mechanisms of different heavy metallic cations (Cd, Ni, Pb) to active chemical groups on the cell wall matrix of the nonliving brown marine macroalga, Sargassum vulgaris in its natural form, were examined by the following instrumental and chemical techniques: Fourier-transform infrared (FTIR) analysis, X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), a...

Nucleation-dependent protein aggregation ("seeding") and amyloid fibril-free formation of soluble SDS-resistant oligomers ("oligomerization") by hydrophobic interaction is an in vitro model thought to propagate beta-amyloid (Abeta) deposition, accumulation, and incur neurotoxicity and synaptotoxicity in Alzheimer's disease (AD), and other amyloid-associated neurodegenerative diseases. However, ...

background: cadmium (cd) is an extremely toxic metal and environmental exposure to cd has been particularly problematic in the world. oral exposure to cd may result in adverse effects on a number of tissues, the immune system, and the cardiovascular system. compounds containing cd are also carcinogenic. the presence of cd in drinking water resources in the southeastern region of rafsanjan plain...

Chelation therapy is thought to not only remove contaminating metals but also to decrease free radical production. However, in standard ethylene diamine tetracetic acid (EDTA) chelation therapy, high doses of vitamin C with potential pro-oxidant effects are often added to the chelation solution. The authors demonstrated previously that the intravenous administration of the standard chelation co...

There is accumulating evidence that interactions between beta-amyloid and copper, iron, and zinc are associated with the pathophysiology of Alzheimer's disease (AD). A significant dyshomeostasis of copper, iron, and zinc has been detected, and the mismanagement of these metals induces beta-amyloid precipitation and neurotoxicity. Chelating agents offer a potential therapeutic solution to the ne...