The enzyme-guided asymmetric synthesis of (+)-verbenone from geranyl diphosphate in a simple two-step, one pot transformation highlights the potential of chemoenzymatic procedures for the generation of high-value terpenoids.

practical chemoenzymatic and chemical routes to uridine 5'-diphospho-N'acetylglucosamine (UDP-GlcNAc) on r !ruscale have been developed. The chemoenzymatic synthesis provided convenient access to glucosaminigpnosphate and N-acetylgluiosamine&phosphatc (GlcNAc-GP) in )lGmmol quantities. The condensation betweenblcNAc-6-P and UTi, was catalyzed by readily available crude enzyme extracts from drie...

The tremendous structural heterogeneity of N-glycosylation of glycoproteins poses a great challenge for deciphering the biological functions of specific glycoforms and for developing protein-based therapeutics. We have previously reported a chemoenzymatic glycan remodeling method for producing homogeneous glycoforms of N-glycoproteins including intact antibodies, which consist of endoglycosidas...

We report a unified chemoenzymatic asymmetric synthesis of five prostaglandins, featuring two enzymatic redox transformations and copper(ii)-catalyzed regioselective p-phenylbenzoylation.

A small library of novel germacrenes was generated using a combination of two plant enzymes, germacrene A synthase, and D synthase and modified farnesyl diphosphate (FDP) analogues. This chemoenzymatic approach allows the preparation of potentially valuable volatiles for biological studies.

We report a new chemoenzymatic strategy for the rapid and sensitive detection of O-GlcNAc posttranslational modifications. The approach exploits the ability of an engineered mutant of beta-1,4-galactosyltransferase to selectively transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins. Once transferred, the ketone moiety serves as a versatile handle for the attachment of ...

A chemoenzymatic method for the synthesis of haloethers is presented. combination enzymatic hypohalite with spontaneous oxidation alkenes and nucleophilic attack by various alcohols enabled a wide range haloethers. The reaction system has been characterised current imitations have worked out. In present, aqueous system, hydroxyhalide formation represents main undesired side reaction. Neverthele...

(-)-gephyrotoxin-223 was formally synthesized from chiral synthon 1 which has been chemoenzymatically synthesized  in the presence  of candida antartica lipase.

The self-assembly behavior of chemoenzymatic high molecular weight (ca. 30 000 Da) poly-l-phenylalanine (ePLP) and the nano-morphologies thereof are investigated.

Aqueous chemoenzymatic two-step one-pot enantioselective synthesis of tertiary α-aryl cycloketones via Pd-catalyzed C–C formation and enzymatic CC asymmetric hydrogenation was developed.