Over the past decade, it was widely accepted that some chemotherapeutic drugs can be combined with immunotherapeutic drugs in treatment of cancer. Chemotherapeutic drugs can induce apoptosis in the tumor cell and at the same time stimulate the immune response. Several reports support the use   immunomodulators in treatment of cancers through regulating the immune response and boosting the micro...

We examined the effects of two different drugs (cladribine and mitoxantrone), which are frequently used in chemotherapeutic treatment, on human serum paraoxanase1 (PON1) enzyme activity vitro. Chemotherapeutic decreased vitro PON1 activity. Cladribine mitoxantrone inhibition mechanism were not competitive inhibitors. IC50 values for cladribine calculated as 0.077 mM 0.099 mM, respectively, Ki c...