the application of chemotherapy in cancer treatment has been limited due to cause side effects such as toxicity against normal cells and drug resistance. in recent years, numerous studies have been focused on using natural products with chemotherapeutic drugs to enhance therapeutic efficiency and reduce cytotoxicity. on the other hand, encapsulation of drugs into nanoparticles (nps) can improve...

To study the feasibility of combined hyperthermic and anticancer drug treatment for peritoneal cancer, we devised a continuous hyperthermic peritoneal perfusion system in combination with mitomycin C. The model uses i.p.-transplantable rat ascites hepatoma 100B cells. Hyperthermic peritoneal perfusion alone or combined with mitomycin C was performed after i.p. inoculation of the tumor cells int...

The application of chemotherapy in cancer treatment has been limited due to cause side effects such as toxicity against normal cells and drug resistance. In recent years, numerous studies have been focused on using natural products with chemotherapeutic drugs to enhance therapeutic efficiency and reduce cytotoxicity. On the other hand, encapsulation of drugs into nanoparticles (NPs) can improve...

Apoptosis or programmed cell death is a common property of multicellular organisms (Danial and Korsmeyer, 2004; Krammer, 2000). It can be triggered by a number of factors, including UVor γ-irradiation, chemotherapeutic drugs or signaling by death receptors (DR). The DR family is part of the tumor necrosis factor receptor superfamily (Bhardwaj and Aggarwal, 2003). Triggering members of the DR fa...

Introduction Canine transmissible venereal tumor (CTVT) is classified as a round cell tumor. It always revealed in round to ovoid shaped cell, moderate amount of vacuolated cytoplasm with a large round to ovoid nucleus and prominent nucleoli (2). However, Amaral et al. (2007) reported that CTVT cytomorphology was classified into three types according to the majority of cell type population: pla...