Chandra, R. K. (1975). Archives of Disease in Childhood, 50, 559. Lymphocyte response to hepatitis B surface antigen: findings in hepatitis and Indian childhood cirrhosis. The lymphocyte delayed hypersensitivity response to phytohaemagglutinin (PHA) and hepatitis B antigen (HBsAg) was evaluated by two in vitro tests-leucocyte migration inhibition and DNA synthesis. Patients convalescing from HB...

Perkash, A., Nair, A., Bhorchi, R., and Walia, B. N. S. (1971). Archives of Disease in Childhood, 46, 45. Haemolytic anaemia in Indian childhood cirrhosis. Fifty-five patients with Indian childhood cirrhosis were investigated for the occurrence of haemolysis and for its possible underlying mechanisms. Increased haemolysis was present in 76°/o of patients, and was severe in 12%. The degree of an...

Historical background and past knowledge: The infantile and childhood variety of Cirrhosis was first described by Sen from Bengal in 1887 [3]. Earlier, it was known by the name ‘infantile cirrhosis’ or ‘infantile biliary cirrhosis’, based on a few clinicopathological accounts of the disease. In 1950s, the disease gained public health importance on account of its high prevalence, unique clinical...

Cirrhosis of the liver is rare in childhood in the temperate zone and it is then usually due to some specific and traceable cause, such as Rhesus incompatibility, galactosaemia, congenital syphilis, in association with congenital abnormalities of the biliary apparatus, or following infective hepatitis. In most of the subtropics and tropics-at least according to present probably incomplete evide...