A simple, precise and rapid, reversed phase-high performance liquid chromatography (RP-HPLC) method is developed for simultaneous determination of chlordiazepoxide and amitriptyline hydrochloride in tablet dosage forms. The HPLC conditions used are methanol: acetonitrile (75:25 v/v) mobile phase, Zodiac C18 column (250mm x 4.6mm x 5μm), pump pressure (9.5 MPa) and detection wavelength (221 nm)....

Administration of the benzodiazepine triazolam at the appropriate time in the circadian cycle has been shown to induce phase shifts in hamster circadian rhythms. These phase shifts can be blocked by geniculo-hypothalamic tract (GHT) ablation or by restraint of activity. The present study examined the effects of the benzodiazepine chlordiazepoxide on running-wheel activity rhythms of hamsters. T...

Antipsychotic drugs at noncataleptic doses selectively suppress conditioned avoidance response in rats. In our previous study, we had used a two-way active avoidance response paradigm to show that the antipsychotic-induced interoceptive state is one of the mechanisms underlying the avoidance-disruptive effect of antipsychotics. In this study, we sought to further examine this mechanism using a ...

The effect of co-administration of ketamine at the sub-effective dose with diazepam, chlordiazepoxide and clonazepam on their antinociceptive and protective efficacy against pentetrazole-induced seizures were studied in mice. Ketamine alone produces dose-dependent antinociception manifested as reduction in the number of writhing episodes evoked by acetic acid. In the writhing test, the antinoci...

CRYSTALS OF THE HYDROGEN SULFATE SALT OF CHLORDIAZEPOXIDE (SYSTEMATIC NAME: 7-chloro-N-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-iminium 4-oxide hydrogen sulfate), C(16)H(15)ClN(3)O(+)·HSO(4) (-), were obtained from a solution of chlordiazepoxide and sulfuric acid in methanol. The structure features chlordiazepoxide mol-ecules that are protonated at the imine N atom. The seven-membered...

BACKGROUND Currently, benzodiazepines are the preferred drugs in the management of alcohol withdrawal symptoms. Chlordiazepoxide and diazepam, the most frequently used drugs have a long duration of action and are converted to active metabolites in the liver, while lorazepam is shorter acting, with no active metabolites. OBJECTIVE To compare and evaluate the safety and efficacy of lorazepam an...

The effects of chronic administration of haloperidol and chlordiazepoxide for 14 days on self-stimulation behavior were investigated in rats with electrodes chronically implanted in the lateral hypothalamus. Haloperidol produced a prominent decrease in self-stimulation behavior during chronic treatment, followed by a significant increase in the lever-pressing rate during a 2 week withdrawal per...

Three reliable, rapid and selective methods have been developed and validated for the determination of imipramine and chlordiazepoxide in pharmaceutical dosage forms. The first method is spectrophotometric method includes simultaneous estimation method, first order derivative spectrophotometric method, isoabsorptive method and multiwavelength method. All variables affecting the reaction have be...