The chlorobenzene degradation pathway of Pseudomonas sp. strain P51 is an evolutionary novelty. The first enzymes of the pathway, the chlorobenzene dioxygenase and the cis-chlorobenzene dihydrodiol dehydrogenase, are encoded on a plasmid-located transposon Tn5280. Chlorobenzene dioxygenase is a four-protein complex, formed by the gene products of tcbAa for the large subunit of the terminal oxyg...

Atmospheric transport is the major route for global distribution of semi-volatile compounds such as halogenated aromatics as well as their major exposure route for humans. Their major atmospheric removal process is oxidation by hydroxyl radicals. There is very little information on the reaction mechanism or reaction-path dynamics of atmospheric degradation of halogenated benzenes. Furthermore, ...

Pseudomonas putida GJ31 has been reported to grow on chlorobenzene using a meta-cleavage pathway with chlorocatechol 2,3-dioxygenase (CbzE) as a key enzyme. The CbzE-encoding gene was found to be localized on the 180 kb plasmid pKW1 in a cbzTEXGS cluster, which is flanked by transposases and encodes only a partial (chloro)catechol meta-cleavage pathway comprising ferredoxin reductase, chlorocat...

Naphthalene, anthracene and phenanthrene are metabolized in rats and rabbits to 1:2-dihydroxy compounds which have been proved to be 1:2dihydro-1:2-diols (Young, 1950; Boyland, 1950). In the benzene series, an o-dihydroxy compound, 4-chlorocatechol, is a major metabolite of chlorobenzene in the rabbit (Spencer & Williams, 1950; Smith, Spencer & Williams, 1950). Many monosubstituted benzenes, e....

Di-tert-butyl peroxide (DTBP) and 2, 2'-azobisisobutyronitrile (AIBN) were used as initiators and chlorobenzene was used as an inert solvent. The values of kp/(2kt)1/2 in the neat phase are slightly less than those in chlorobenzene solution for a given initiator concentration and temperature. This retardation can be attributed to the solvent effect of chlorobenzene on the decomposition rate of ...

A Pd-based heterogeneous catalyst (Pd(II)-MCM-41) derived from post-synthesis modification of mesoporous silica, MCM-41, has been successfully employed in catalytic Stille and Sonogashira cross-coupling reactions. The catalyst affords good yields in all cross-coupling reactions. Notably, the catalyst is capable of activating less reactive chlorobenzene with moderate yield in both the coupling r...

Chlorobenzene is a colorless volatile compound widely used as an organic solvent or a chemical intermediate. There is, however, a potential risk for people engaged in the manufacture and the handling of this compound. The threshold limit value of the time-weighted average (TLV-TWA) for chlorobenzene in air has been set at 75 ppm (350 mg/m3).1) Animals exposed to chlorobenzene excrete this compo...

A series of 1,2,4-trisubstituted-1H- imidazole derivatives (4a-o) was synthesized by reacting 2,4-disubstituted-1H-imidazoles (3a-o) with chlorobenzene in the presence of triethylamine. Phenylglyoxal (2) was reacted with different aromatic aldehydes in the presence of ammonium acetate and glacial acetic acid to afford the disubstituted imidazoles (3a-o). The structures of the synthesized compou...