Like other manifestations of the rheumatic state chorea is subject to spontaneous remissions and relapses which make the assessment of the action of any particular therapy notoriously difficult. Furthermore, objective measurements of the degree of chorea seem necessary to confirm clinical impressions of an increase or decrease of chorea. With this in mind certain objective methods of assessing ...

OBJECTIVE To develop an evidence-based guideline assessing pharmacologic options for treating Huntington disease (HD) chorea. METHODS We evaluated available evidence from a structured literature review performed through February 2011. RESULTS AND RECOMMENDATIONS If HD chorea requires treatment, clinicians should prescribe tetrabenazine (up to 100 mg/day), amantadine (300-400 mg/day), or ril...

BACKGROUND Although tetrabenazine, a drug that depletes presynaptic dopamine by inhibiting vesicular monoamine transporter 2 (VMAT2), was approved by the U.S. Food and Drug Administration in 2008 for the treatment of chorea associated with Huntington's disease (HD), there is a paucity of data on its long-term efficacy and safety. METHODS Approximately 2,000 patients with a variety of hyperkin...

Chorea is a hyperkinetic movement disorder characterised by excessive spontaneous movements that are irregularly timed, randomly distributed and abrupt. In this article, the authors discuss the causes of chorea, particularly Huntington's disease and the genetic syndromes that may resemble it, including HDL1-3, inherited prion disease, spinocerebellar ataxias 1, 3 and 17, neuroacanthocytosis, de...

Chorea is an uncommon clinical manifestation of Sytemic lupus erythematosus (SLE). Its pathogenic mechanism has not been clearly clarified. We report a 54-year-old woman with SLE who presented with generalized chorea as an initial manifestation. Fluorine-18-fluorodeoxyglucose (FDG) PET revealed increased metabolism in the bilateral putamen. Intravenous and oral administration of steroid markedl...

Chorea is a rare complication of polycythemia. We report the case of a 70 year-old woman whose polycythemia vera (PV), with Janus Kinase-2 (JAK2) mutation, presented as chorea. Chorea resolved quickly after hydroxyurea therapy.

Chorea refers to irregular, flowing, non-stereotyped, random, involuntary movements that often possess a writhing quality referred to as choreoathetosis. When mild, chorea can be difficult to differentiate from restlessness. When chorea is proximal and of large amplitude, it is called ballism. Chorea is usually worsened by anxiety and stress and subsides during sleep. Most patients attempt to d...

Chorea is a hyperkinetic movement disorder characterized by excessive spontaneous movements that are irregularly timed, randomly distributed and abrupt. Chorea in an elderly patient poses a diagnostic challenge. The differential diagnosis is broad and includes medication effects, vascular disorders, metabolic abnormalities, autoimmune syndromes and neurodegenerative disorders.1,2 Important caus...