PURPOSE Transforming growth factor-beta (TGF-beta) plays an important role in the development of choroidal neovascularization. TGF-beta transduces signals through the mediation of type I and type II receptors. We investigated the expression of TGF-beta receptors in a normal rat retina and a model of experimentally induced choroidal neovascularization. METHODS Choroidal neovascularization was ...

Purpose: Choroidal osteoma is a rare tumor which features intraocular bone formation. This tumor can be complicated by choroidal neovascularization which is a cause of impaired vision in this condition. We present a case of choroidal osteoma with choroidal neovascularization as a complication. Methods: Case report with clinical and angiographic correlation. Results: A 16 year old female present...

We report an unusual case of choroidal neovascularization secondary to intraocular foreign body (IOFB) penetrating trauma. A 44-year-old man was referred to our department for IOFB trauma in the right eye. Vitrectomy and IOFB extraction was performed with good visual results. However, 2 months after surgery, he returned complaining of a drop in visual acuity. Choroidal neovascularization origin...

Choroidal neovascularization (CNV) is one of the hallmark symptoms Wet Age-related Macular Degeneration (wAMD) and DiabeticRetinopathy(DR) which involves formation neoangiogenic i.e. new abnormal blood vessels emerging from choroidal protruding through retinal layer. The current management wAMD intravitreal injections anti-VEGF such as ranibizumab aflibercept. We hypothesized delivery small mol...

PURPOSE Choroidal neovascularization (CNV) accounts for 90% of cases of severe vision loss in patients with advanced age-related macular degeneration. Identifying new therapeutic targets for CNV may lead to novel combination therapies to improve outcomes and reduce treatment burden. Our goal was to test whether phosphatidylserine (PS) becomes exposed in the outer membrane of choroidal neovascul...

Inflammatory choroidal neovascularization is a severe but uncommon complication of uveitis, more frequent in posterior uveitis such as punctate inner choroidopathy, multifocal choroiditis, serpiginous choroiditis, and Vogt-Koyanagi-Harada syndrome. Its pathogenesis is supposed to be similar to the wet age related macular degeneration: hypoxia, release of vascular endothelial growth factor, stro...

PURPOSE To emphasize the effect of an inflammatory event like lens extraction on choroidal neovascularization. CASE REPORT A 56-year-old woman was referred due to decreased vision in the right eye after bilateral clear lens extraction. The anterior segment examination was unremarkable and intraocular lenses were in the bag of both eyes. Fundus examination of the right eye revealed a choroidal...

PURPOSE To evaluate the effect of placental growth factor (PlGF) gene knockdown in a murine model of laser-induced choroidal neovascularization. METHODS Choroidal neovascularization was induced in the left eyes of 11 mice by infrared laser. Small interfering RNA (siRNA, 20 picomoles/10 μl) corresponding to PlGF mRNA was administered intravitreally by Hamilton syringe in all subjects. One mont...

INTRODUCTION Keratoconus and choroidal neovascularization can occur as a result of dysfunction of the epithelium and its basement membrane. CASE PRESENTATION A 17-year-old Asian man, who was diagnosed with myopic choroidal neovascularization in both eyes and who subsequently underwent intravitreal injection of ranibizumab (Lucentis(R)) five times over six months, presented with further vision...