نتایج جستجو برای: chromosomal integration

تعداد نتایج: 268172  

2010
Federico Andrea Santoni Oliver Hartley Jeremy Luban

Upon cell invasion, retroviruses generate a DNA copy of their RNA genome and integrate retroviral cDNA within host chromosomal DNA. Integration occurs throughout the host cell genome, but target site selection is not random. Each subgroup of retrovirus is distinguished from the others by attraction to particular features on chromosomes. Despite extensive efforts to identify host factors that in...

Journal: :Genetics 1999
P Ng M D Baker

Gene targeting using sequence insertion vectors generally results in integration of one copy of the targeting vector generating a tandem duplication of the cognate chromosomal region of homology. However, occasionally the target locus is found to contain >1 copy of the integrated vector. The mechanism by which the latter recombinants arise is not known. In the present study, we investigated the...

Journal: :Genome research 2007
Hinco J Gierman Mireille H G Indemans Jan Koster Sandra Goetze Jurgen Seppen Dirk Geerts Roel van Driel Rogier Versteeg

Transcription factor complexes bind to regulatory sequences of genes, providing a system of individual expression regulation. Targets of distinct transcription factors usually map throughout the genome, without clustering. Nevertheless, highly and weakly expressed genes do cluster in separate chromosomal domains with an average size of 80-90 genes. We therefore asked whether, besides transcript...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Peter Melsheimer Svetlana Vinokurova Nicolas Wentzensen Gunther Bastert Magnus von Knebel Doeberitz

PURPOSE Increasingly deregulated expression of the E6-E7 oncogenes of high-risk human papillomaviruses (HR-HPVs) has been identified as the major transforming factor in the pathogenesis of cervical dysplasia and derived cancers. The expression of these genes in epithelial stem cells first results in chromosomal instability and induces chromosomal aneuploidy. It is speculated that this subsequen...

Journal: :The journal of the Japanese Society of Lymphoreticular Tissue research 1999

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