Brucellosis is a zoonotic disease that is still endemic in developing countries. Despite early diagnosis and treatment of patients, chronic infections are seen in 10-30% of patients. In this study, we aimed to investigate the immunological factors that play roles in the transition of brucellosis from acute infection into chronic infection. Here, more than 2000 miRNAs were screened in peripheral...

BACKGROUND Brucellosis is one of the most common chronic diseases, with widespread distribution. In spite of cell-mediated immunity (CMI) modulated mainly via activated T-helper type 1 (Th1) cells, brucellosis can advance to chronic disease in about 10-30% of cases. Regulatory T cells (Treg cells) are involved the immune response to brucellosis; however, their role, particularly in the change f...

Abstract Objective Brucellosis is a zoonosis almost chronic disease. bacteria can remain in the environment for long time. Thus, climate irregularities could pave way survival of bacterium brucellosis. more common men 25 to 29 years age, western provinces, and spring months. The aim this study investigate effect climatic factors as well predicting incidence brucellosis Qazvin province using Mar...

Objective: Brucellosis is a systemic zoonosis that affects various organs or body systems and can mimic many diseases. Symptoms range from acute febrile illness to chronic clinical manifestations with severe complications. In our study, we investigated the relationship between bacteremia laboratory findings, complications in patients brucellosis.
 Material Methods: Two hundred twenty-three...

disease. That it should be so rare in India is surprising considering that Polding (1947) reported that 10 per cent to 50 per cent of aborting Indian cattle in certain rural areas were infected with brucellosis and so long as we have brucellosis among cattle we will have the disease among human beings. The fact however is that even 85 per cent of cases of acute brucellosis are missed, being tak...

Although our knowledge about Brucella virulence factors and the host response increase rapidly, the mechanisms of immune evasion by the pathogen and causes of chronic disease are still unknown. Here, we aimed to investigate the immunological factors which belong to CD8+ T cells and their roles in the transition of brucellosis from acute to chronic infection. Using miRNA microarray, more than 20...

Serum samples from all patients with culture-confirmed brucellosis including those with chronic disease from Kazakhstan tested positive in the serum agglutination test for titers > or = 1:25 and reacted in the Brucella immunoglobulin M/immunoglobulin G lateral flow assay (LFA) confirming the high sensitivity of these assays. The strong reactivity in the LFA observed for the majority (92.1%) of ...

Introduction Brucellosis is one of the most widespread zoonosis in the world. Only 17 countries informed WHO that their territory is free from brucellosis. About 500 thousand cases of brucellosis in humans are registered in the world each year. The problem of brucellosis has remained actual to agriculture and health care for many years. Almost all agricultural animals are highly susceptible to ...

Background and objectives: Brucellosis is an acute or chronic illness manifested principally by chills and fever. Occasionally, chronic relapsing febrile episodes occur. Brucellosis is endemic in animal and humans are infected incidentally. The aim of the study was to examine the incidence of brucellosis in Erbil City, study the relation between the rate of infection and a number of predisposin...

conclusions this infection was observed with a diversity of clinical manifestations. therefore, diagnostic difficulty because of the various clinical presentations and the way to find undiagnosed complications should be investigated in the differential diagnosis of other diseases. results most of the patients (73.8%) were in the acute stages of brucellosis, 22.6% had sub-acute brucellosis and 3...