CLASP is a key regulator of microtubule (MT) dynamics and bipolar mitotic spindle structure with CLASP mutants displaying a distinctive monopolar spindle phenotype. It has been postulated that cryptic TOG domains underlie CLASP’s ability to regulate MT dynamics. Here, we report the crystal structure of a cryptic TOG domain (TOG2) from human CLASP1, demonstrating the presence of a TOG array in t...

To compare the gastroesophageal junction of the human with the pig, M(2) and M(3) receptor densities and the potencies of M(2) and M(3) muscarinic receptor subtype selective antagonists were determined in gastric clasp and sling smooth muscle fibers. Total muscarinic and M(2) receptors are higher in pig than human clasp and sling fibers. M(3) receptors are higher in human compared with pig slin...

The rehabilitation of a patient in the Kennedy class IV situation demands biomechanical balance and aesthetic improvement. The long-span condition complicates the problem because of the unavailability of sufficient number of abutments to support the prosthesis. Conventional removable prosthesis and fixed partial denture are not advised for the same reason. This report describes a novel techniqu...

During chromosome segregation, kinetochores form dynamic connections with spindle microtubules. In vertebrates, these attachments require the activities of a number of outer kinetochore proteins, including CENP-F [1, 2] and the widely conserved microtubule-associated protein CLASP [3]. Here, we investigate the functional relationship between HCP-1/2, two redundant CENP-F-like proteins, and CLAS...

We propose a procedure for the evaluation of characteristics clasps removable partial dentures made thermoplastic materials. The includes following stages: specific pressure clasp on retaining tooth, determination maximum internal forces and stresses in clasp, finding its shape unloaded state. results our investigations enable us to choose optimal sizes order create required holding force dentu...

We present the new multi-threaded version of the state-of-the-art answer set solver clasp. We detail its component and communication architecture and illustrate how they support the principal functionalities of clasp. Also, we provide some insights into the data representation used for different constraint types handled by clasp. All this is accompanied by an extensive experimental analysis of ...

INTRODUCTION Stresses resulting from cast clasp arms during insertion and the removal of removable partial dentures are the main causes of deformations or fractures. Therefore, achieving clasp designs producing less stress is very important. OBJECTIVE Retentive clasp arms used for premolars were investigated through the reverse engineering approach. The aim was to determine stress distributio...

PURPOSE The objective of this study was radiographic assessment of the premolar teeth abutments alveolar bone resorption in mandibular Kennedy Class I removable partial denture (RPD) utilizing the broad stress distribution philosophy, either designed with multiple circlet clasp or compound Aker clasp. MATERIALS AND METHODS Twelve patients were enrolled for this study with upper completely ede...

Spatial regulation of microtubule (MT) dynamics contributes to cell polarity and cell division. MT rescue, in which a MT stops shrinking and reinitiates growth, is the least understood aspect of MT dynamics. Cytoplasmic Linker Associated Proteins (CLASPs) are a conserved class of MT-associated proteins that contribute to MT stabilization and rescue in vivo. We show here that the Schizosaccharom...

Amniote epiblast cells differentiate into mesoderm and endoderm lineages during gastrulation through a process called epithelial-to-mesenchymal transition (EMT). Molecular regulation of gastrulation EMT is poorly understood. Here we show that epiblast epithelial status was maintained by anchoring microtubules to the basal cortex via CLIP-associated protein (CLASP), a microtubule plus-end tracki...