Introduction: Laparoscopy can be used as an adjunct to successfully treat hepatocellular carcinoma nodules, the surgeon manipulates liver under direct visualization. To perform laparoscopic assisted thermal ablation must skilled at ultrasound identify tumor nodule(s). In this study we introduce a novel microwave via IV infusion of indocyanine green (ICG) dye. Methods: 25 patients with cirrhosis...

BACKGROUND T1-weighted (T1W) hyperintense nodules against a background of cirrhosis are diagnostically challenging in daily practice. All regenerative nodules, dysplastic nodules and hepatocellular carcinoma (HCC) might present hyperintense on T1W imaging (T1WI), so T1W hyperintense nodules cannot be definitively characterized as dysplastic nodules or HCC before biopsy, resection or transplanta...

Liver masses in cirrhosis are increasingly being recognized with the use of new imaging modalities. The majority of these lesions are detected by ultrasound, enhanced CT and MRI. The most likely diagnosis of a solid liver lesion in a cirrhotic liver is hepatocellular carcinoma, followed by high grade or low grade dysplastic nodule, and cholangiocarcinoma. Lymphoma and liver metastasis are extre...

Cirrhotic nodules were assumed to be a mixture of ellipsoids of different sizes and eccentricities, and mathematical derivations were discussed to estimate the distribution, the mean and the standard deviation of their sizes with only a small number of random histological sections. Logarithms of the largest axes of nodules approximately formed a normal distribution. With intermediate results, t...

In September 2001, during follow-up at our outpatient liver unit we detected by ultrasound a hypervascular mass adjacent to the VI hepatic segment in a 78-year-old HCV-positive cirrhotic woman. Subsequently abdominal computed tomography (CT) revealed an infiltrative vascularized nodule (3.5 cm in diameter) at the lower border of the VI hepatic segment and magnetic resonance imaging showed a “te...

BACKGROUND Splenosis is a heterotropic implantation of splenic fragments onto exposed vascularised peritoneal and intrathoracic surfaces, following splenic injury or elective splenectomy. CASE PRESENTATION A 60 year old cirrhotic patient was referred to us with a hepatic mass, suspected to be HCC in a cirrhotic liver. A computerized tomography scan (CT) demonstrated a cirrhotic liver with a 2...

UNLABELLED Hepatocellular carcinoma (HCC) is rare in the Netherlands, even though the incidence has increased quite sharply in recent years. Standard treatment options consist of surgery, orthotopic liver transplantation, radiofrequency ablation, transarterial chemoembolisation (TACE) and systemic therapy with sorafenib. The consensus-based Dutch HCC guideline, established in 2013, serves to gu...

RATIONALE Lack of an experimental model of portopulmonary hypertension (POPH) has been a major obstacle in understanding of pathophysiological mechanisms underlying the disease. OBJECTIVE We investigated the effects of CCl4-mediated cirrhosis on the pulmonary vasculature, as an initial step towards an improved understanding of POPH. METHODS AND RESULTS Male C57BL/6 mice received intraperito...