antidepressants—specifically clomipramine, fluoxetine, paroxetine, and sertraline—are best and have been shown to improve symptoms of premature ejaculation (strength of recommendation [sor]: a, meta-analysis of randomized controlled trials [rcTs]). The topical application of prilocaine-lidocaine cream (trade name eMla) improves intravaginal ejaculatory latency time (IelT), but penile numbness a...

Introduction: We evaluated the efficacy of citalopram and sertraline in the treatment of premature ejaculation (PE). Materials and Methods: Of 101 married men with PE, 80 were eligible and consented to participate in this randomized controlled trial. Erectile dysfunction and administration of drugs for the treatment of PE were the exclusion criteria. The patients were evaluated using index of p...

BACKGROUND In our previous study, significantly higher antioxidant enzymes and malondialdehyde (MDA) levels in patients with premature ejaculation (PE) compared to healthy controls were found. In the present study, we planned to evaluate antioxidant enzymes and MDA levels of patients with PE before and after citalopram treatment. METHODS The study comprised 30 patients with PE according to Di...

BACKGROUND Sleep disturbance is a common complaint in major depressive disorder (MDD) including impairment of both subjective and objective parameters. All antidepressants affect sleep architecture and quality. AIM This trial was designed to compare the effects of short-term use of citalopram with fluoxetine on sleep quality (SQ) of patients with MDD based on Diagnostic and Statistical Manual...

Serotonin specific reuptake inhibitors (SSRI) may induce antinociception however, the mechanism of this effect is not clear. SSRls increase 5-HT levels in neuronal synapses and facilitate serotonergic activity. In this study, therefore, the activity of para-chlorophenylalanine (pCPA), which reduces 5-HT release, and 5- hydroxy tryptophan (5-HTP), a precursor of 5-HT, were examined on the a...

serotonin specific reuptake inhibitors (ssri) may induce antinociception however, the mechanism of this effect is not clear. ssrls increase 5-ht levels in neuronal synapses and facilitate serotonergic activity. in this study, therefore, the activity of para-chlorophenylalanine (pcpa), which reduces 5-ht release, and 5- hydroxy tryptophan (5-htp), a precursor of 5-ht, were examined on the antino...

Erectile dysfunction, otherwise known as impotency, affects more than 30 million men each year, yet only about 200,000 seek help from a physician. Impotency remains largely unrecognized simply because most men do not discuss sexual problems with their doctors. In addition, many physicians do not ask or are uncomfortable dealing with the subject. Erectile dysfunction is defined as the inability ...