BACKGROUND Breast cancer remains a leading cause of death in women worldwide. Although breast cancer therapies have greatly advanced in recent years, many patients still develop tumour recurrence and metastasis, and eventually succumb to the disease due to chemoresistance. Citral has been reported to show cytotoxic effect on various cancer cell lines. However, the potential of citral to specifi...

Cymbopogon citratus has been shown to have antioxidant, antimicrobial, antispasmodic and chemo-protective properties. Citral, is the major constituent of C. citratus. This study investigated the effects of methanolic extracts of leaves (LE), stems (SE), and roots (RE) of C. citratus and citral on vascular smooth muscle and explored their possible mechanisms of action. The experiment was conduct...

Two essential oils of Lippia alba (Mill.) N.E. Brown (Verbenacea), the carvone and citral chemotypes and 15 of their compounds were evaluated to determine cytotoxicity and antifungal activity. Cytotoxicity assays for both the citral and carvone chemotypes were carried out with tetrazolium-dye, which showed a dose-dependent cytotoxic effect against HeLa cells. Interestingly, this effect on the e...

In systemic therapy, chemotherapeutic drugs, often, cause considerable side effects; and combination of natural compounds lessen the extent of such effects. In the present study, combined effect of citral and 5-fluorouracil was studied in Schizosaccharomyces pombe cells. The antagonistic combination index found was at 0.01 and 0.025 mM of citral with 40 μg or higher concentration of 5-fluoroura...

T H E effects of vitamin A and citral on the differentiation of chick tracheal epithelium in vitro were described in a previous paper (Aydelotte, 1963a). High concentrations of vitamin A inhibited the development of tracheal mucous cells but the epithelium became well ciliated. Citral in low concentrations favoured the differentiation of mucous cells but few ciliated cells developed; in higher ...

Citrus bacterial canker (CBC) caused by Xanthomonas citri subsp. citri (Xcc), is the most devastating of the citrus diseases worldwide. During our study, we found that Essential oils (EOs) of some citrus cultivars are effective on Xcc. Therefore, it prompted us to determine the plant metabolites responsible for the antibacterial properties. We obtained EOs from some locally cultivated citrus by...

We have demonstrated that a combination of enantiopure 2-diarylmethylpyrrolidines and heterogeneous Pd/BaSO(4) is an efficient catalytic system for the asymmetric hydrogenation of citral, specifically, a mixture of E-citral and Z-citral in any ratio, and that citronellal is obtained with high enantioselectivity. This dual catalyst system provides a new and more economical route to L-menthol.

Lemongrass (Cymbopogon citratus Stapf.) is a common herb used in cooking and recognized for its many health benefits. This study measured the antioxidant activity and citral content in lemongrass extracts made from air-dried and fresh plants by decoction and infusion. The plants were collected from one area each from three different municipalities in Iloilo (Pavia, Jaro and Lapaz) and two baran...

PURPOSE The unmanageable side effects caused by current chemotherapy regimens to treat cancer are an unresolved problem. Although many phytonutrients are useful as chemoprevention without side effects, their effects are slower and smaller than conventional chemotherapy. In the present work, we examined the cumulative effect of two phytonutrients, curcumin and citral, on breast cancer cell lines...

T H E effects of vitamin A and citral on the differentiation of chick tracheal epithelium in vitro were described in a previous paper (Aydelotte, 1963a). High concentrations of vitamin A inhibited the development of tracheal mucous cells but the epithelium became well ciliated. Citral in low concentrations favoured the differentiation of mucous cells but few ciliated cells developed; in higher ...