Introduction: Cleft lip and palate, the most common developmental deformity, is seen worldwide and the etiology involves a combination of genetic and environmental factors. The purpose of this study was to determine the maternal risk factors associated with the development of cleft lip and cleft palate. Materials and Methods: We conducted a case control study at the Women’s Hospital in Culiacan...

Background and aim: Cleft lip and cleft palate are among the most common orofacial abnormalities. Patients with these deformities commonly present with midface deficiency and need challenging treatment modalities that focus on improving the position of the maxilla. Tongue plate appliance is an intraoral device that has shown promising results in the treatment of growing patients with maxillary ...

a 39-year-old pregnant woman at 38 weeks of gestation was referred with labor pain to a hospital. she had consanguinity with her husband. a female newborn had multiple craniofacial anomalies and phocomelia in right upper limb. the disease locus was assigned to chromosome17q21. four days later, infant died of cardiopulmonary arrest.

introduction: cleft lip and palate are among the most common congenital anomalies worldwide. this study was conducted in order to explore the incidence and related factors of cleft lip and/or palate (cl/p) among live births in mashhad, north-eastern iran.   materials and methods: in this cross-sectional study, records of 28,519 infants born between march 1982 and march 2011 at three major hospi...

results no significant difference was found between the groups regarding bmht rs3797546 gene polymorphism. the c allele was not associated with ns-cl/p (or = 1.27, 95% ci = 0.85-2.79, p = 0.690). conclusions our data suggested that bmht rs3797546 gene polymorphism was not associated with risk/ protection for ns-cl/p in a sample of iranian population. larger studies are required to validate our ...

background and aims. the aim of the present study is to determine the incidence of mthfr c677 t and a1298c mutations in iranian patients with cleft lip and/or cleft palate. materials and methods. we screened 61 iranian patients with cleft lip and/or cleft palate for mutations in the two alleles of mthfr gene associated with cleft lip and/or palate: a1298c and c677t, using polymerase chain react...

introduction: treatment ofcleft lip and palate patients requires a multidisciplinary plan. these patients usually have a hypoplastic maxilla due to the prior surgical scars. orthognathic surgery to advance the maxilla in these patients is not very efficient; therefore, orthopedic interventions during an appropriate age seems to be essential.   case report: in this article, two cleft lip and pal...

orofacial clefts, including cleft lip with or without cleft palate (cl (p)), are common congenital malformations, second only to clubfoot in frequency of occurrence. the epidemiology and genetics of this disorder have been studied extensively in various countries by several investigators. the objective of this study is to assess the epidemiology and some genetic aspects of orofacial clefting at...