Behavioral effects of methyl angolensate were investigated in mice and rats. Spontaneous motor activity, pentobarbital sleeping time, amphetamine-stereotyped behaviour, exploratory activity and apomorphine-induced climbing studies in mice were evaluated. The results revealed that methyl angolensate reduced spontaneous motor activity in mice, prolonged the duration of pentobarbital sleeping time...

Mechanical loads play a significant role in determining long bone shape and strength, but less work has explored how these loads influence flat bones like the scapula, which has been shown to vary with locomotor preference among primate taxa. Here, we tested the effects of voluntary running and climbing exercise in mice to examine how the mechanical loads borne from different locomotor patterns...

Objectives: The aim of the study is to evaluate antidepressant activity ethanolic extract leaves Moringa oleifera L. (EEMO) on albino mice. Methods: anti-depressant was evaluated using forced swimming test (FST) and tail suspension (TST). Healthy mice were individually swim inside a vertical glass cylinder. Climbing, swimming, immobility tested recorded. In TST, suspended string held by metal s...

The effects of target loss on adult axonal arbors were investigated by comparing the morphological changes of adult climbing fibers in several mutant mouse strains where Purkinje cells slowly degenerate (namely, Lurcher, nervous, Purkinje cell degeneration, and tambaleante), with those occurring after a fast Purkinje cell death induced by mechanical lesions of the adult mouse cerebellum. In eac...

Introduction: In this study the antidepressant effect of a new morpholino betalactam composition, 1-(3- morpholinopropyl)-4-(naphthalene-2-yl)-3-phenoxyazetidin-2-one (EB9) administered at three doses, was investigated in an animal model of depression. The CNS stimulant, muscle coordination and toxic effects of this compound were also tested. Methods: Morpholino betalactam at 10, 15 and 20 ...

The cerebellum is an area of the brain that plays a crucial role in the learning of motor skills. This process involves climbing fibers, which provide teaching signals to Purkinje cells in the cerebellar cortex when perturbations occur during a movement. However, controversy has arisen over climbing fibers contribution to cerebellar learning. This is because climbing-fiber signals are described...

A series of experiments examined the ability of dopamine D3/D2 receptor agonists [(+)-(4aR,10bR)-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]b enzopyrano-[4,3-b]-1,4-oxazin-9-ol hydrochloride (PD 128,907), (+/-)-7-hydroxy-dipropylaminotetralin hydrobromide (7-OH-DPAT), quinpirole and bromocriptine] to produce a variety of dopaminergically mediated behaviors. The effects of these drugs with selectiv...

A unique feature of the cerebellar architecture is that Purkinje cells in the cerebellar cortex each receive input from a single climbing fiber. In mice deficient in the gamma isoform of protein kinase C (PKCgamma-/- mice), this normal architecture is disrupted so that individual Purkinje cells receive input from multiple climbing fibers. These mice have no other known abnormalities in the cere...

Long-term inhibition of D2 dopamine receptors using classic D2 dopamine receptor antagonists such as haloperidol often causes a compensatory up-regulation of the D2 dopamine receptors. We investigated whether the long-term inhibition of D2 dopamine receptors using an eukaryotic expression vector housing a cDNA sequence encoding an antisense RNA directed to the D2 dopamine receptor transcript (D...