The speaker gave a brief review of published reports on the medical therapy of vitiligo in the last five years. First of all, the use of topical agents was discussed. Fifty percent of the patients had more than 75% of their lesions repigmented after 0.1% tacrolimus treatment. The efficacy was comparable to clobetasol propionate. There was limited data on pimecrolimus but a trial showed that its...

the aim of the present study was to investigate the potential of nanoemulsion formulation for topical delivery of clobetasol propionate (cp) using algal oil (containing omega-3 fatty acids) as the oil phase. cp has anti-inflammatory, immunomodulatory and antiproliferative activities. however, its clinical use is restricted to some extent due to its poor permeability across the skin. algal oil w...

Sir, Topical corticosteroids (TCS) are an integral part of dermatological therapeutics. The clinical effects of TCS depend on the structure of the molecule, the vehicle and the skin onto which it is applied.[1] Addition of a fluorine molecule at six and/ or nine positions enhances the potency of TCS. Halobetasol propionate has 6α flouro clobetasol 17-propionate as the active ingredient. Very oc...

OBJECTIVE To assess the safety and efficacy of topical 0.1% tacrolimus vs 0.05% clobetasol propionate. DESIGN Randomized double-blind trial. SETTING Department of Dermatology, Hospital Central Dr Ignacio Morones Prieto, San Luis Potosí, México. PARTICIPANTS From 20 children with vitiligo, 2 symmetrical lesions of about the same size and evolution time were selected. They were devoid of an...

Table I. Patients’ own opinion regarding eYcacy after 12 Sir, months Calcipotriol, a vitamin D derivative, has proven to be eVective in the treatment of nail psoriasis (1–4). The Hands (n= 48) Feet (n= 53) purpose of this open study was to evaluate the eYcacy n (%) n (%) and safety of the combined treatment of nail psoriasis Poor 3 (6.2) 6 (11.3 ) with calcipotriol cream and clobetasol propiona...

The physical and chemical degradation of drugs may result in altered therapeutic efficacy and even toxic effects. Therefore, the objective of this work was to study the stability of clobetasol propionate (CP) in a nanoemulsion. The nanoemulsion formulation containing CP was prepared by the spontaneous emulsification method. For the formulation of the nanoemulsion, Safsol, Tween 20, ethanol, and...

Topical corticosteroids have been the cornerstone of treatment over last six decades for various dermatoses characterized by dry, scaly, crusted, or erythematous skin as well those associated with inflammation and pruritus. The potency a topical steroid depends on specific molecule, amount drug reaching target, absorption through (0.25%–3%), formulation. Clobetasol propionate (CP) 0.025% cream ...

PURPOSE We report our experience with the use of a topical steroid, 0.05% clobetasol propionate, for the treatment of phimosis with clinical complications. MATERIALS AND METHODS This was a retrospective analysis of the clinical outcomes of all patients presenting with phimosis to a single institution during the time period from October 2008 to May 2012. A total of 88 patients who had a Kikiro...

OBJECTIVE We sought to describe the response of patients with severe erosive gingival lesions to treatment with clobetasol propionate in Orabase paste administered in trays. The adverse effects were also recorded. STUDY DESIGN A descriptive pretest/posttest clinical study with no control group (33 patients total) was developed. All patients received repeated applications of 0.05% clobetasol p...