نتایج جستجو برای: clustered corm percent

تعداد نتایج: 127265  

2017
Charlotte Sahlberg Bang Isak Demirel Robert Kruse Katarina Persson

Treatment of urinary tract infections is today a challenge due to the increasing prevalence of multidrug-resistant ESBL-producing uropathogenic Escherichia coli (UPEC). There is an urgent need for new treatment strategies for multidrug-resistant UPEC and preferably with targets that have low potential for development of resistance. Carbon monoxide-releasing molecules (CORMs) are novel and poten...

Journal: :Microbiology 2009
Lígia S Nobre Fátima Al-Shahrour Joaquin Dopazo Lígia M Saraiva

We recently reported that carbon monoxide (CO) has bactericidal activity. To understand its mode of action we analysed the gene expression changes occurring when Escherichia coli, grown aerobically and anaerobically, is treated with the CO-releasing molecule CORM-2 (tricarbonyldichlororuthenium(II) dimer). Microarray analysis shows that the E. coli CORM-2 response is multifaceted, with a high n...

Journal: :The Journal of clinical investigation 2014
Jing Xue Aida Habtezion

The protective role of hemeoxygenase-1 (HO-1) in various inflammatory conditions is mediated in part by its products, carbon monoxide (CO) and biliverdin. Here we investigated a therapeutic role for CO and CO-primed cells in acute pancreatitis (AP). In a mouse model of AP, treatment with CO-releasing molecule-2 (CORM-2) decreased mortality, pancreatic damage, and lung injury. CORM-2 decreased s...

2010
Hoda Mamdouh Hassan

The growing need for a trustworthy Future Internet demands evolutionary approaches unfettered by legacy constrains and concepts. The networking community is calling for new network architectural proposals that address the deficiencies identified in present network realizations, acknowledge the need for a trustworthy IT infrastructure, and satisfy the society's emerging and future requirements. ...

2013
Elena A. Sher Mati Shaklai Nurith Shaklai

Carbon monoxide releasing molecules (CORMs) have been recently developed for research and pharmacological purposes. A considerable amount of studies demonstrated a wide spectrum of biological activities for lipophilic CORM-2 (tricarbonyldichlororuthenium (II) dimer). It is generally accepted that the liberated gas provides the specific activities to CORMs, with a little attention paid to any po...

Journal: :Rheumatology 2008
M I Guillén J Megías V Clérigues F Gomar M J Alcaraz

OBJECTIVES Previous work has shown that the CO-releasing molecule CORM-2 protects against cartilage degradation. The aim of this study was to examine whether CORM-2 can control the production of inflammatory mediators in osteoarthritic chondrocytes and determine the mechanisms involved. METHODS Primary cultures of chondrocytes from OA patients were stimulated with IL-1beta. The production of ...

Journal: :Free radical biology & medicine 2011
Luisa Lo Iacono Jorge Boczkowski Roland Zini Issam Salouage Alain Berdeaux Roberto Motterlini Didier Morin

Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase, is an important signaling mediator in mammalian cells. Here we show that precise delivery of CO to isolated heart mitochondria using a water-soluble CO-releasing molecule (CORM-3) uncouples respiration. Addition of low-micromolar concentrations of CORM-3 (1-20 μM), but not an inactive compound that does ...

2012
Steve Lancel David Montaigne Xavier Marechal Camille Marciniak Sidi Mohamed Hassoun Brigitte Decoster Caroline Ballot Caroline Blazejewski Delphine Corseaux Bernadette Lescure Roberto Motterlini Remi Neviere

AIMS Metabolic syndrome induces cardiac dysfunction associated with mitochondria abnormalities. As low levels of carbon monoxide (CO) may improve myocardial and mitochondrial activities, we tested whether a CO-releasing molecule (CORM-3) reverses metabolic syndrome-induced cardiac alteration through changes in mitochondrial biogenesis, dynamics and autophagy. METHODS AND RESULTS Mice were fed...

Journal: :Kidney & blood pressure research 2013
Martina Feger Abul Fajol Aleksandra Lebedeva Adrian Meissner Diana Michael Jakob Voelkl Ioana Alesutan Erwin Schleicher Christoph Reichetzeder Berthold Hocher Syed M Qadri Florian Lang

BACKGROUND/AIMS Carbon monoxide (CO) interferes with cytochrome-dependent cellular functions and acts as gaseous transmitter. CO is released from CO-releasing molecules (CORM) including tricarbonyl-dichlororuthenium (II) dimer (CORM-2), molecules considered for the treatment of several disorders including vascular dysfunction, inflammation, tissue ischemia and organ rejection. Cytochrome P450-s...

2006
William M. Mason William Lavely

No official public use micro-sample of the 1990 Chinese census has yet been released. There are, however, two extant micro-samples of the census that have circulated within China and abroad. The first, in order of creation, is a one percent sample of administrative villages. The second is a one percent sample of households. We refer to the former, the subject of this article, as the “one percen...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید