Objective(s): Comparative in vivo studies were carried out to determine the adsorption characteristics of amitriptyline (AMT) on activated charcoal (AC) and sodium polystyrene sulfonate (SPS). AC has been long used as gastric decontamination agent for tricyclic antidepressants and SPS has showed to be highly effective on in-vitro drugs adsorption. Materials and Methods: Sprague-Dawley male rats...

Low peak plasma concentrations (Cmax) of amikacin and gentamicin are reported in intensive care unit (ICU) patients after administration of the first dose. The present study aimed to describe the proportion of ICU patients in whom an adequate Cmax was achieved throughout the course of therapy. Septic ICU patients with an indication for intravenous amikacin or gentamicin were eligible for inclus...

Aims: The aim of this study was to evaluate the pharmacokinetic profiles and relative bioavailability dexketoprofen thiocolchicoside test preparation (dexketoprofen / 25 mg 8 effervescent tablet) in comparison with reference preparations (Keral film coated tablet, containing trometamol equivalent (Menarini International Operations Luxembourg S.A.) (R1) Muscoril capsule, (Sanofi Aventis İlaçları...

Background There is scant evidence to support target drug exposures for optimal tuberculosis outcomes. We therefore assessed whether pharmacokinetic/pharmacodynamic (PK/PD) parameters could predict 2-month culture conversion. Methods One hundred patients with pulmonary tuberculosis (65% human immunodeficiency virus coinfected) were intensively sampled to determine rifampicin, isoniazid, and p...

Abstract Background Anticoagulation and antiplatelet therapy, mainstays for the prevention of thromboembolic disorders, are associated with an increased bleeding risk. Asundexian, a novel, potent reversible oral inhibitor factor XIa, is independent extrinsic coagulation pathway thus not expected to increase Purpose To determine absolute bioavailability (FAB), assess impact gastric pH modulators...

Let there be m parallel machines and n jobs, where a job j can be scheduled on machine i to take pi, j ∈ Z+ time units. The makespan Cmax is the completion time of a machine that finishes last. The goal is to produce a schedule with all n jobs that has minimum makespan. This is the makespan problem on unrelated parallel machines, denoted as R||Cmax. Assume p,q ∈ Z+ are constants, let A(p,q) = {...

background: closantel is a broad-spectrum antiparasiticagent and is widely used for the control of fasciola spp. andhaemonchus spp. infestations in sheep and cattle. objectives:the present study was carried out to evaluate the bioequivalenceof a domestic closantel formulation, fascinil® (damloranpharmaceutical co., iran), in comparison with flukiver®(janssen pharmaceutical co., belgium) in shee...

AIM Circulating concentrations of endogenous compounds such as testosterone, complicate the analysis of pharmacokinetic parameters when these compounds are administered exogenously. This study examines the influence of three correction methods of accounting for endogenous concentrations on the determination of bioequivalence between two testosterone formulations. METHODS 12 healthy males rece...