MicroRNAs (miRNAs) are small non-coding RNAs with the unique ability to degrade or block specific and regulate many cellular processes. Neuroinflammation plays pivotal role in occurrence development of multiple central nervous system (CNS) diseases. The miRNAs enhance restrict neuroinflammatory signaling pathways CNS diseases is an emerging important research area, including neurodegenerative d...

Prion diseases or transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases, clinically characterised by cognitive decline, paralleled by severe damage to the central nervous system. Prion diseases have attracted a broad interest because of their unique mechanisms of replication and propagation; however, the underlying pathogenic mechanisms are still highly speculati...

Astrocytes play a crucial role in the maintenance of normal functions Central Nervous System (CNS). During pathogenesis neurodegenerative diseases, astrocytes undergo morphological and functional remodeling, process called reactive astrogliosis, response to insults CNS. One key aspects is change expression function connexins. Connexins are channel proteins that highly expressed astrocytes, form...

The complexity and organization of the central nervous system (CNS) is widely modulated by presence blood–brain barrier (BBB) blood–cerebrospinal fluid (BCSFB), which both act as biochemical, dynamic obstacles impeding any type undesirable exogenous exchanges. disruption these barriers usually associated with development neuropathologies can be consequence genetic disorders, local antigenic inv...

Many human diseases relating to central nervous system (CNS) are mimicked in animal models to evaluate the efficacy of stem cell therapy. The therapeutic role of stem cells in animal models of CNS diseases include replacement of diseased or degenerated neuron, oligodendrocytes or astrocytes with healthy ones, secretion of neurotrophic factors and delivery of therapeutics/genes. Scaffolds can be...