Platelet aggregation inhibitory effect and anticoagulant properties of fractions separated from the venoms of Cerastes persicus fieldi and Echis carinatus were investigated. The partial fractionation was performed on a Sephadex G-100 column. Two fractions separated from Cerastes persicus fieldi showed anti platelet aggregation activity on ADP (200 µM)-induced platelet aggregation (ca 80% inhibi...

Multiple sclerosis (MS) is a neuroinflammatory autoimmune disease which mediated by various molecular and cellular immune components However Recent reports have shown that coagulation factors that traditionally separate from the immune system might also be involved in MS development and progression.studies on experimental autoimmune encephalomyelitis (EAE) and human MS patients reports alterati...

blood hypercoagulability or thrombogenicity can be one of the main causes of the cardiovascular diseases in young population without traditional pathologic risk factors such as diabetes mellitus, hypertension or hyperlipidemia. the effect of aerobic exercise on coagulation and fibrinolysis has been studied extensively regarding to the effectivness of resistance exercises to increase functional ...

platelet aggregation inhibitory effect and anticoagulant properties of fractions separated from the venoms of cerastes persicus fieldi and echis carinatus were investigated. the partial fractionation was performed on a sephadex g-100 column. two fractions separated from cerastes persicus fieldi showed anti platelet aggregation activity on adp (200 µm)-induced platelet aggregation (ca 80% inhibi...

Blood hypercoagulability or thrombogenicity can be one of the main causes of the cardiovascular diseases in young population without traditional pathologic risk factors such as diabetes mellitus, hypertension or hyperlipidemia. The effect of aerobic exercise on coagulation and fibrinolysis has been studied extensively Regarding to the effectivness of resistance exercises to increase functional...

Critically ill patients often have systemic activation of both inflammation and coagulation. Increasing evidence points to an extensive cross-talk between these two systems, whereby inflammation not only leads to activation of coagulation, but coagulation also considerably affects inflammatory activity. The intricate relationship between inflammation and coagulation may have major consequences ...

........................................................................................................................ 9 INTRODUCTION ............................................................................................................... 11 REVIEW OF THE LITERATURE ...................................................................................... 13 1. Platelets .....................

Organophosphates (OPs) are potentially able to affect serine proteases by reacting with their active site. The potential effects of OPs on coagulation factors such as thrombin and on coagulation tests have been only partially characterized and potential interactions with OPs antidotes such as oximes and muscarinic blockers have not been addressed. In the current study, we investigated the in vi...

Although multiple sclerosis (MS) has been associated with the coagulation system, the temporal and spatial regulation of coagulation activity in neuroinflammatory lesions is unknown. Using a novel molecular probe, we characterized the activity pattern of thrombin, the central protease of the coagulation cascade, in experimental autoimmune encephalomyelitis. Thrombin activity preceded onset of n...