Safety and efficacy of lumefantrine-artemether (Coartem(R)) for the treatment of uncomplicated Plasmodium falciparum malaria in Zambian adults Malaria Journal 2006, 5:73 doi:10.1186/1475-2875-5-73 Modest Mulenga ([email protected]) Jean-Pierre Van geertruyden ([email protected]) Lawrence Mwananyanda ([email protected]) Victor Chalwe ([email protected]) Filip Moerman (fmoer...

The mechanisms of drug resistance development in the Plasmodium falciparum parasite to lumefantrine (LUM), commonly used in combination with artemisinin, are still unclear. We assessed the polymorphisms of Pfmspdbl2 for associations with LUM activity in a Kenyan population. MSPDBL2 codon 591S was associated with reduced susceptibility to LUM (P = 0.04). The high frequency of Pfmspdbl2 codon 591...

In Nigeria, it was reported in 2009 that 84 children were killed as a result of toxic chemicals that were laced with teething medications for babies [1]. In 2012, Angolan custom agents busted counterfeiters importing what turned out to be the largest fake medicine imports in history, when containers shipped from China to Luanda were filled with over 1.4 million packets of fake antimalarial drug...

background: malaria remains the world’s most devastating human parasitic infection. our goal was to assess the capacity of increasing concentrations of five antimalarial drugs (fansidartm, halfantm, quinine, coartemtm and chloroquine phosphate) to elicit the generation of methemoglobin in three human erythrocyte genotypes (hb aa, hb as and hb ss). materials and methods: spectrophotometric metho...

BACKGROUND This study sought to determine the level of adherence to Coartem© in the routine treatment of uncomplicated malaria among children under the age of five years in Nyando district, Kenya. METHODS Seventy-three children below the age of five years with microscopically confirmed uncomplicated Plasmodium falciparum malaria and prescribed Coartem(®) during the normal outpatient departmen...

Malaria still has in Kenya a high mortality and morbidity rate; this is coupled with rising resistance levels to the new standard drug Coartem several South Asian countries, according WHO reports. Homeopathy can be considered form of individualized immune therapy as such it deserves place next treatments focused at microorganisms themselves. These factors require scientific evidence that may su...

Coartem(®), the combination of artemether (an artemisinin derivative) and lumefantrine, has been adopted as the first-line treatment for uncomplicated malaria in many countries. The emergence of resistance to artemisinin derivatives has now been proven in South-East Asia, and there is concern that this may spread to other endemic areas. Strategies to contain and control the spread of artemisini...