Platinating compounds including cisplatin, carboplatin, and oxaliplatin are common chemotherapeutic agents, however, patients developed resistance to these clinical agents after initial therapeutic treatments. Therefore, different approaches have been applied to identify novel therapeutic agents, molecular mechanisms, and targets for overcoming drug resistance. In this study, we have identified...

Cobalt pi-complexes, previously described in the literature and specially synthesized and characterized in this work, were used as catalysts in homogeneous oxidation of organic compounds with peroxides. These complexes contain pi-butadienyl and pi-cyclopentadienyl ligands: [(tetramethylcyclobutadiene)(benzene)cobalt] hexafluorophosphate, [(C₄Me₄)Co(C₆H₆)]PF₆ (1); diiodo(carbonyl)(pentamethylcyc...

The important role of the vitamin B12 coenzyme (FIGURE 1) in biochemiStryl and the discovery of a relatively easy method of conversion of the cobalamins to the coenzymes as well as a wide variety of cobalt-alkyl and cobalt-acyl analogues2 • .s,4.1i has stimulated a thorough examination of the structure, properties, and reactions of these unique compounds, which are the first examples of stable ...

BACKGROUND Cobalt has been shown to induce mainly asthma, allergic contact dermatitis and hard metal disease. The data on cobalt asthma are mainly based on case reports. AIMS To characterize all the cases of occupational cobalt asthma encountered in a cobalt plant at the time of diagnosis and 6 months later. We also evaluated the incidence of cobalt asthma in different departments on the basi...

β-diketone-cobalt complexes, a family of newly synthesized non-platinum metal compounds, exhibit potential antitumor activity; however, the antitumor mechanism is unclear. The current study investigated the mechanism by which β-diketone-cobalt complexes inhibit rat C6 glioma cell proliferation. It was found that β-diketone-cobalt complexes suppress rat C6 glioma cell viability in a dose-depende...

Reactions of dicobalt octacarbonyl [Co2(CO)8] with 2'-deoxy-5-oxopropynyluridines and related compounds gave dicobalt hexacarbonyl nucleoside complexes (83-31 %). The synthetic outcomes were confirmed by X-ray structure determination of dicobalt hexacarbonyl 2'-deoxy-5-(4-hydroxybut-1-yn-1-yl)uridine, which exhibits intermolecular hydrogen bonding between a modified base and ribose. The electro...

Field-induced slow magnetic relaxation was observed for air-stable mononuclear cobalt(II) compounds with pentagonal bipyramid geometry. These are the first examples of such behavior observed in the seven-coordinated mononuclear 3d metal compounds.

— The K X-ray absorption discontinuity of cobalt in the compounds of the RCo5 family (R = rare earth or yttrium) has been measured with a bent crystal spectrograph. It is observed that the main discontinuity shifts to the low energy side, with respect to that in pure cobalt indicating a flow of charge from R to Co. The plot between the observed shifts and the number of covalently bonded electro...

A novel palladium-catalyzed C-H double carbonylation introduces two adjacent carbonyl groups for the synthesis of isatins from readily available anilines. The reaction proceeds under atmospheric pressure of CO with high regioselectivity and without any additives. Density functional theory investigations indicate that the palladium-catalyzed double carbonylation catalytic cycle is plausible.