Introduction: Coenzyme Q10 is a powerful antioxidant that has the ability to reduce the damage caused by oxidative stress and is predominantly found in the inner mitochondrial membrane. This study was conducted to determine the effect of coenzyme Q10 on neuropathic pain in an animal model of spinal cord injury. Methods: In order to induce neuropathic pain, thoracic segments of the spinal cor...

BACKGROUND High oxidative stress and chronic inflammation can contribute to the pathogenesis of coronary artery disease (CAD). Coenzyme Q10 is an endogenous lipid-soluble antioxidant. Statins therapy can reduce the biosynthesis of coenzyme Q10. The purpose of this study was to investigate the effects of a coenzyme Q10 supplement (300 mg/d; 150 mg/b.i.d) on antioxidation and anti-inflammation in...

background: heavy exercise cause muscle damage associated with production of inflammatory agents. the purpose of present study was to determine the effect of acute and 14-day coenzyme q10 supplementation on inflammatory, blood lactate and muscle damage in male middle-distance runners.   methods : eighteen male middle-distance runners in a randomized and quasi experimental study were allocated i...

PURPOSE OF REVIEW Coenzyme Q10 is administered for an ever-widening range of disorders, therefore it is timely to illustrate the latest findings with special emphasis on areas in which this therapeutic approach is completely new. These findings also give further insight into the biochemical mechanisms underlying clinical involvement of coenzyme Q10. RECENT FINDINGS Cardiovascular properties o...

The potential protective effect of coenzyme Q10 against acute liver injury induced by a single dose of acetaminophen (700 mg/kg, p.o.) was investigated in rats. Coenzyme Q10 treatment was given as two i.p. injections, 10 mg/kg each, at 1 and 12 h following acetaminophen administration. Coenzyme Q10 significantly reduced the levels of serum aminotransferases, suppressed lipid peroxidation, preve...

OBJECTIVE The purpose of this study was to investigate the effect of coenzyme Q10 supplementation on oxidative stress and antioxidant enzyme activity in patients with coronary artery disease (CAD). METHODS This was an intervention study. Patients who were identified by cardiac catheterization as having at least 50% stenosis of one major coronary artery or receiving percutaneous transluminal c...

In this communication, the concept is developed that coenzyme Q10 has a toti-potent role in the regulation of cellular metabolism. The redox function of coenzyme Q10 leads to a number of outcomes with major impacts on sub-cellular metabolism and gene regulation. Coenzyme Q10's regulatory activities are achieved in part, through the agency of its localization in the various sub-cellular membrane...

Nanocapsule suspensions containing coenzyme Q10 were prepared by interfacial deposition. The nanocapsules showed characteristics compatible with dermal application: slightly acid pH, drug content close to 100%, particle size between 213 and 248 nm with low polydispersity and negative zeta potential. Three cosmetic formulations for skin application were developed, one with the free-coenzyme Q10,...

The present study was designed to investigate the potential protective effect of Coenzyme Q10 against the testicular toxicity of cadmium in male rabbits. Four groups of animals were used in this study (control, Coenzyme Q10, cadmium chloride-treated (5 mg/kg), cadmium chloride plus Coenzyme Q10 (10 mg/kg) for 30 days). Results showed normal testicular tissue in control and coenzyme Q10 groups. ...

background community-acquired pneumonia (cap) is generally considered a major cause of morbidity and mortality in the elderly. objectives this study aimed to assess the efficacy of adjunctive coenzyme q10 (coq10) in the treatment of elderly cap. conclusions coq10 administration has no serious side effects and can improve outcome in hospitalized elderly cap; therefore, we recommend it as an adju...