BACKGROUND Since the 1930s, the environment has become increasingly obesogenic, leading to rising rates of adiposity and socioeconomic inequalities in adiposity. Building on studies comparing body mass index (BMI) for cohorts born over a period of 20 years, we examine the social patterning of BMI and central adiposity for three cohorts born over a 40-year period. METHODS Using data from the W...

inflammatory basis in pathopoiesis of coronary artery disease (cad) have been demonstrated in recent decades. elevated c-reactive protein (crp) and leukocytosis were associated with an elevated risk   for acute coronary syndrome (acs). to evaluate the relationship between quantitative crp and cardiac troponin i in conjunction with white blood cell (wbc) count and 30 days outcomes and treatment ...

BACKGROUND   Many cohort studies have been carried out that have provided information on the relationship between diet and health-related outcomes. Omission of important covariates during multivariate analysis may give rise to error due to residual confounding. A possibly important covariate is socioeconomic status (SES) as this is related to both diet and health. OBJECTIVE To determine the f...

In observational studies of the effect of an exposure on an outcome, the exposure-outcome association is usually confounded by other causes of the outcome (potential confounders). One common method to increase efficiency is to match the study on potential confounders. Matched case-control studies are relatively common and well covered by the literature. Matched cohort studies are less common bu...

BACKGROUND Three longitudinal studies of cancer incidence in varied populations of World Trade Center responders have been conducted. METHODS We compared the design and results of the three studies. RESULTS Separate analyses of these cohorts revealed excess cancer incidence in responders for all cancers combined and for cancers of the thyroid and prostate. Methodological dissimilarities inc...

BACKGROUND Food preferences vary substantially among adults and children. Twin studies have established that genes and aspects of the shared family environment both play important roles in shaping children's food preferences. The transition from childhood to adulthood is characterized by large gains in independence, but the relative influences of genes and the environment on food preferences in...

conclusions this study demonstrated the detection of hcv-specific ifn-γ responses in hcv antibody and rna negative individuals, with a tendency for hcv-specific ifn-γ responses to be associated with hcv exposure. the potential role of hcv-specific ifn-γ responses in those who remained hcv rna negative is of value for the development of novel hcv therapeutics. objectives in a cohort of hcv antib...

conclusions treating obesity, increasing physical activity and quality of married life are proposed as practical solutions to reduce bp. background hypertension is considered as a major public health problem in most countries due to its association with ischemic heart disease which causes cerebrovascular disease and death. objectives the purpose of the present study was to study factors affecti...

BACKGROUND The level of frailty in the older population across age cohorts and how this changes is a factor in determining future care costs and may also influence the extent of socioeconomic and gender inequalities in frailty. METHODS We model cohort-specific trajectories in frailty among the community dwelling population older than 50 years, using five waves (2002-2010) of the English Longi...

Whereas the feasibility and effectiveness of Internet-based epidemiologic research have been established, methodological support for the quality of such data is still accumulating. We aimed to identify sociodemographic differences among members of a French cohort according to willingness to provide part of one's 15-digit national identification number (personal Social Security number (PSSN)) an...