Sulfasalazine is characterized by low intestinal absorption, which essentially enables its colonic targeting and therapeutic action. The mechanisms behind this low absorption have not yet been elucidated. The purpose of this study was to investigate the role of efflux transporters in the intestinal absorption of sulfasalazine as a potential mechanism for its low small-intestinal absorption and ...

the present study , was an attempt to develop galactosylated albumin nanoparticles of simvastatin for treatment of hypercholesterolemia. by developing the galactosylated nanoparticulated delivery the required action of drug at the target site at liver can be provided. the advantage of targeting helps to reduce the systemic side effects which may be occur due to the distribution of the drug to t...

Seventy-six percent of diabetic patients develop gastrointestinal symptoms, such as constipation. However, the direct effects of diabetes on intestinal smooth muscle are poorly described. This study aimed to identify the role played by smooth muscle in mediating diabetes-induced colonic dysmotility. To induce type 1 diabetes, mice were injected intraperitoneally with low-dose streptozotocin onc...

As a pH-sensitive nanomaterial, Eudragit S100 has good colon targeting. However, little research been carried out on its mesoscopic scale. In this paper, the self-assembly behavior of Pulsatilla saponins D (PSD) and S100, as well loading release mechanism PSD, was investigated via computer simulations. The effects characteristics PSD in dry powder state drug-carrier ratio were explored by coars...

BACKGROUND The nuclear receptor peroxisome proliferator-activated receptor-δ/β (PPAR-d) is upregulated in human colorectal cancers, but its role in colonic tumorigenesis remains controversial. METHODS We generated a novel mouse model of intestinally targeted PPAR-d overexpression to simulate PPAR-d upregulation in human colon carcinogenesis. Colon-specific PPAR-d overexpression was confirmed ...

colonic lipoma is a benign neoplasm that can lead to colonic obstruction but concomitant intussusception is rare in adults. in this case, colocolic intussusception due to a lipoma in the descending colon had occurred. by laparatomy, we diagnosed the problem , but reduction was impossible . so resection of the colon with mass was done and anastomosed. after surgery and 3 years follow up the pati...

Occurrence of inflammatory bowel diseases has increased at an alarming rate. The predominant inflammatory bowel diseases are Ulcerative colitis and Crohn’s disease. The treatment and extent of therapy is decided by the severity of the conditions. The most common drugs prescribed in the treatment include anti-inflammatory agents like 5 amino salicylates, corticosteroids and immunosuppressants. C...

Few studies within the pathogenic field have used advanced imaging and analytical tools to quantitatively measure pathogenicity in vivo. In this work, we present a novel approach for the investigation of host-pathogen processes based on medium-throughput 3D fluorescence imaging. The guinea pig model for Shigella flexneri invasion of the colonic mucosa was used to monitor the infectious process ...