background: the protein hormone granulocyte colony-stimulating factor (gcsf) stimulates the production of white blood cells and plays an important role in medical treatment of cancer patients. methods: an efficient process was developed for heterologous expression of human gcsf in e. coli bl21 (de3). the feeding rate was adjusted to achieve the maximum attainable specific growth rate under crit...

background: granulocyte colony stimulating factors (gcsf) are high cost agents commonly recommended for primary and secondary prophylaxis of chemotherapy-induced neutropenia and febrile neutropenia. gcsfs have been shown to be beneficial in some patient subgroups, although they are probably overused in clinical settings. the american society of clinical oncology (asco) guidelines summarize curr...

introduction: various neuroregenerative procedures have been recently employed along with neurorehabilitation programs to promote neurological function after spinal cord injury (sci), and recently most of them have focused on the acute stage of spinal cord injury. in this report, we present a case of acute sci treated with neuroprotective treatments in conjunction with conventional rehabilitati...

introduction genetic background has known to be associated with the outcome of human t cell lymphotropic virus (htlv) type i infection. in the present study we investigate the association between gm-csf gene polymorphisms with the outcome of htlv-i infection. materials and methods we analyzed 3 single-nucleotide polymorphisms in the promter region of granulocyte macrophage colony stimulating fa...

objective(s): granulocyte-colony stimulating factor (g-csf) is used in clinical practice for the treatment of neutropenia and to stimulate generation of hematopoietic stem cells in bone marrow donors. in the present study, the ability of g-csf in mobilizing exogenous bone marrow stem cells (bmscs) from peripheral blood into the brain was tested. we for the first time injected a small amount of ...

two dogs with generalized seizures were evaluated. the dogs were diagnosed with traumatic intracranial hemorrhages based on the history, neurological examinations, and magnetic resonance imaging (mri) of the brain. treatment was started with oxygen, prednisolone and anticonvulsant agents. no further seizure activity was observed after treatment in both dogs, however cushing reflex was detected ...

In this study granulocyte-macrophage colony stimulating factor (CSF) was prepared from rabbit and guinea pig lung tissues. The biological activity of these CSFs was measured on semisolid agar culture and compared with those of mouse and rat. Weight of animals, incubation time and cross-reactivity of CSFs with different bone marrow sources were also investigated. The results showed that both...