PURPOSE Although the clinical efficacy of cyclosporin A (CSA) in retinoblastoma (RB) has been attributed to multidrug resistance reversal activity, the authors hypothesized that CSA is also directly toxic to RB cells through inhibition of calcineurin (CN)/nuclear factor of activated T-cells (NFAT) signaling. METHODS Antiproliferative effects of CSA, PSC-833 (a CSA analogue that does not inhib...

We study the minimal normal completion problem: given A ∈ Cn×n, how do we find an (n+q)×(n+q) normal matrix Aext := ( A A12 A21 A22 ) of smallest possible size? We will show that this smallest number q of rows and columns we need to add, called the normal defect of A, satisfies nd(A) ≥ max{i−(AA∗ −A∗A), i+(AA∗ −A∗A)}, where i±(M) denotes the number of positive and negative eigenvalues of the He...

Different agricultural waste peels were assessed for their suitability to be used as primary substrates for the bioremediation of free cyanide (CN) by a cyanide-degrading fungus Aspergillus awamori isolated from cyanide containing wastewater. The bioremediated CN concentration were in the range of 36 to 110 mg CN/L, with Orange (C. sinensis) > Carrot (D. carota) > Onion (A. cepa) > Apple (M. pu...

An old question of Brauer asking how fast numbers of conjugacy classes grow is investigated by considering the least number cn of conjugacy classes in a group of order 2n. The numbers cn are computed for n ≤ 14 and a lower bound is given for c15. It is observed that cn grows very slowly except for occasional large jumps corresponding to an increase in coclass of the minimal groups Gn. Restricti...

By making use of the symplectic reduction and the cohomogeneity method, we give a general method for constructing Hamiltonian minimal submanifolds in Kaehler manifolds with symmetries. As applications, we construct infinitely many nontrivial complete Hamiltonian minimal submanifolds in CP n and Cn.

The application of IR 786 perchlorate (IR-786) as a selective optical sensor for cyanide anion in both organic solution (acetonitrile (MeCN), 100%) and solvent-free solid surfaces was demonstrated. In MeCN, IR-786 was selective to two anions in the following order: CN(-) > OH(-). A significant change in the characteristic dark green color of IR-786 in MeCN to yellow was observed as a result of ...

In this paper, we prove some Bernstein type results for n-dimensional minimal Lagrangian graphs in quaternion Euclidean space Hn ∼= R. In particular, we also get a new Bernstein Theorem for special Lagrangian graphs in Cn.

The Embassies system [18] turns the web browser model inside out: the client is ultra-minimal, and hence strongly isolates pages and apps; every app carries its own libraries and provides itself OS-like services. A typical Embassies app is 100 MiB of binary code. We have found that the first reaction most people have upon learning of this design is: how can big apps start quickly in such a hars...