At Tihange NPP, spent ion-exchange resins were conditioned by embedding in a polymermatrix with a mobile processing installation. For safety and cost reasons, Electrabeldecided to investigate by which process the former one should be replaced. After a thorough technical economical analysis of the available proven processes, TractebelEngineering selected the Resin Hot Compaction Proc...

The suitability of the new isomalt grade galenIQ™ 801 for dry granulation and following tableting is evaluated in this study. Isomalt alone, as well as a blend of equal parts with dibasic calcium phosphate, is roll compacted and tableted. Particle size distribution and flowability of the granules and friability and disintegration time of the tablets are determined. Tensile strength of tab...

Due to various advantages such as high-precision dosing, manufacturing efficiency and patient compliance helped making tablets the most popular dosage forms among all available dosages forms. Compaction, which is an essential manufacturing step in the manufacture of tablets, mainly includes compression (i.e. reduction of volume of the powder under consideration and particle rearrangement) and c...

Mechanistic pavement design procedures based on elastic layer theory require characterization of all pavement layer materials including subgrade soil. This paper discusses the subgrade stiffness obtained from a new compaction device called the Intelligent Compaction (IC) roller on highway embankment projects in Kansas. Three test sections on two routes were compacted using a single, smooth stee...

Reducing test data size is one of the major challenges in testing systems-on-a-chip. This problem can be solved by test compaction and/or compression techniques. Having a partially specified or relaxed test set increases the effectiveness of test compaction and compression techniques. In this paper, we propose a novel and efficient test relaxation technique for combinational and full-scan seque...

The compression during tabletting is a complex and irreversible dynamic process and the study of it with instrumented tablet presses is beneficial for process and formulation optimization. The compaction and ejection cycle provides us suitable signals about the tabletting process. Instrumented presses used in tabletting research and development are normally equipped to measure punch force and d...

Roller drums make use of various shapes and their dynamic compaction effect is achieved by different kinds of dynamic excitation systems. The bearing capacity of layered soil constructions can be measured during the soil compaction process. The finite element method has been applied for dynamic analyses using elastic models. For the realistic simulation of the dynamic compaction process it is n...

The mechanism of DNA compaction by dendrimers is key to the design of nanotechnologies that can deliver genetic material into cells. We present atomistic simulations, mesoscopic modeling and single-molecule pulling experiments describing DNA dendrimer interactions. All-atom molecular dynamics were used to characterize pulling-force-dependent interactions between DNA and generation-3 PAMAM amine...

SUMMARY Roller compacted hydrophilic polymer combinations were used to formulate verapamil hydrochloride (HCl) extended release hydrophilic matrix tablets. The effect of roller compaction (RC) parameters on the properties of blended polymers, tablets and drug release were investigated. RC granulation improved the powder properties without affecting the pharmacotechnical properties or the drug r...

The compaction of soils used for crop production is becoming an increasingly important consideration in South Africa following the shift towards reduced tillage and increased mechanisation of in-season operations and harvesting. The intensification of dairying has also been found to have a deleterious effect on soil quality, particularly in terms of compaction by trampling, which results in los...