INTRODUCTION Ewing's sarcomas is a rare primitive neuroectodermal tumour (PNET) which has an annual incidence of 2.9 /million population in USA 1Jeffery Toretsky et al (2008) They are very uncommon in African and Asian population. It is commonly associated with reciprocal translocation between chromosome 11 and 12 t (11:12) or less frequently the t(21;22)(q22;ql 2) translocation. It is highly a...

The vacuolar-type ATPase (V-ATPase) is a multisubunit protein composed of the cytosolic adenosine triphosphate (ATP) hydrolysis catalyzing V 1 complex, and integral membrane o , responsible for proton translocation. largest subunit a, enables translocation upon ATP hydrolysis, mediated by complex. Four known isoforms (a1–a4) are expressed in different cellular locations. Subunit a1 (also as a1)...

The majority of patients with acute promyelocytic leukemia (APL) manifest the t(15;17)(q24.1;q21.2) translocation; however, a minor but significant proportion of patients with APL harbor complex, cryptic, or variant translocations, which typically involve RARA. With the exception of ZBTB16/RARA, these variants have similar morphologic and immunophenotypic features as classic APL. Study of the v...

Background: Chronic myeloid leukemia (CML) is characterized by Philadelphia (Ph) chromosome. The Ph detected by karyotyping in 90% CML but 5-10% may have variant translocation where another chromosome addition to chromosome # 9 and 22. The aim of present report is to describe a rare three-way translocation with rarely describe 8p21 breakpoint. Case report: Retrospective cytogenetic database bet...

Background: Spontaneous abortion (SAb) is the most common complication of early pregnancy. Numerous risk factors are associated with an increased risk of pregnancy loss such as: Maternally age, previous spontaneous abortion, prolonged ovulation to implantation, Gravidity, Interval Prolonged time to pregnancy, Balanced chromosomal translocations and Genetic disorders. The aim of this study was t...

In this paper. (1) We determine the complex-valued solutions of the following variant of Van Vleck's functional equation $$int_{S}f(sigma(y)xt)dmu(t)-int_{S}f(xyt)dmu(t) = 2f(x)f(y), ;x,yin S,$$ where $S$ is a semigroup, $sigma$ is an involutive morphism of $S$, and $mu$ is a complex measure that is linear combinations of Dirac measures $(delta_{z_{i}})_{iin I}$, such that for all $iin I$, $z_{...

The t(9;22)(q34;q11) translocation is found in about 90% of chronic myeloid leukemia (CML) patients. About 5-10% of CML patients have complex variant translocations involving a third chromosome in addition to chromosomes 9 and 22. Herein, we describe a CML-chronic phase male with a complex translocation involving chromosome 16, t(9;22;16)(q34;q11;q24). First, he was treated with interferon-alph...

The Philadelphia (Ph(1)) chromosome arising from the reciprocal t(9;22) translocation is found in more than 90% of chronic myeloid leukemia (CML) patients and results in the formation of the chimeric fusion gene BCR-ABL. However, a small proportion of patients with CML have simple or complex variants of this translocation, involving various breakpoints in addition to 9q34 and 22q11. We report f...