Some actions of Org NC 45 have been compared with those of pancuronium in a study on 50 patients anesthetized with nitrous oxide and narcotic supplements. The train-of-four technique was used to assess the recovery of neuromuscular blockade and its antagonism. Org NC 45 was shown to have a duration of action from injection of the intubating dose (0.1 mg kg-1) to the reappearance of the first tw...

The recent crisis made it evident that replicating the performance of a benchmark is not a sufficient goal to meet the expectations of usually risk-averse investors. The manager should also consider that the investor are seeking for a downside protection when the benchmark performs poorly and thus they should integrate a form of downside risk control. We propose a multiperiod double tracking er...

The non-depolarizing neuromuscular block produced by Org NC 45 was potentiated by the previous administration of suxamethonium 1 mg kg-1, shown by twitch depression of 91.3 +/- 2.4% when the same dose of Org NC 45 was administered after recovery from suxamethonium compared with the control value of 71.9 +/- 6.5%. The recovery index was also prolonged from 8.1 +/- 0.3 to 10.4 +/- 1.0 min after s...

There has been an increase in the use of pre-admission selection tests for medicine. Such tests need to show good psychometric properties. Here, we use a paper by Emery and Bell [2009. The predictive validity of the Biomedical Admissions Test for pre-clinical examination performance. Med Educ 43:557-564] as a case study to evaluate and comment on the reporting of psychometric data in the field ...

Vecuronium is hydrolyzed in the body to 3-deacetyl (ORG 7268), 17-deacetyl (ORG NC58), and 3, 17-bis-deacetyl (ORG 7402) derivatives. Interactions of vecuronium and these metabolites were studied in phrenic nerve-hemidiaphragm preparations of rats. As already reported, ORG 7268 had a potent neuromuscular blocking action, and ORG NC58 and ORG 7402 had a weak neuromuscular blocking action. As exp...

Org NC 45 60-80 microgram kg-1 was administered to 20 pregnant women undergoing general anaesthesia for Caesarean section. Org NC 45 plasma concentrations were measured fluorimetrically in samples of maternal, venous and arterial cord blood obtained at delivery. The venous cord to maternal concentration ratio averaged 11% and was not influenced by the interval between induction and delivery. Th...