We have developed an automated system for the design of laboratory experiments in molecular biology. The system uses a planning method known as skeletal plan refinement that attempts to emulate the human cognitive task of experiment design. This paper describes the theory, history, and implementation of the design system and illustrates its function in the domain of DNA cloning experiments.

CBM (“Compressed Baryonic Matter”) is an experiment being prepared to operate at the future Facility for Anti-Proton and Ion Research (FAIR) in Darmstadt, Germany, from 2018 on. CBM will explore the high-density region of the QCD phase diagram by investigating nuclear collisions from 2 to 45 GeV beam energy per nucleon. Its main focus is the measurement of very rare probes (e.g. charmed hadrons...

Independent reproducibility is essential to the generation of scientific knowledge. Optimizing experimental protocols to ensure reproducibility is an important aspect of scientific work. Genetic or pharmacological lifespan extensions are generally small compared to the inherent variability in mean lifespan even in isogenic populations housed under identical conditions. This variability makes re...

A computational approach to the optimization of fracture resistance of multiphase materials (here high speed steels) by varying their microstructure is presented. The main points of the optimization of steels are as folIows: (1) development and verification of the model: numerical simulation of crack initiation and growth in real microstructures of steels, (2) computational experiment: simulati...