نتایج جستجو برای: concentration response curve

تعداد نتایج: 1418229  

  In this study we investigated the bronchodilatory and anticholinergic effects of the aqueous extract (AE), brewed extract (BE) and ethanol extract (EE) of Polygonum avicular in comparison with saline (S) on isolated tracheal chains of the guinea pig. Due to the probable confounding effect of ethanol in the EE, the effects of this extract were also compared with 96 % ethanol. None of the plant...

A GHANNADI, H SADRAEISADRAEI, M MOHSENI, V HAJHASHEMI,

Teucrium polium L. (Lamiaceae) is used in the traditional medicine of Iran for the treatment of disorders of the gastrointestinal tract. The essential oil from the aerial parts of T polium was assessed for antispasmodic activity and compared with the effect of atropine and dicyclomine. Acetylcholine and KC I were used for induction of contraction on rat isolated ileum. Teucrium polium essen...

H SADRAEI, V HAJHASHEMI,

Ketotifen is a benzocycloheptathiophene with a range of pharmacological activities. The present study was carried out to evaluate the action of ketotifen on isolated rat bladder contractions induced by KCI and acetylcholine, compared with the effects of other drugs. Ketotifen (5 µM) reduced the response to acetylcholine on rat isolated bladder without altering the maximum response and shift...

The stimulatory effect of the extract of Portulaca oleracea (P. olerace) on β-adrenoceptor of tracheal smooth muscle was examined. To examine β-adrenoceptor stimulatory effect, concentration response curve to isoprenaline was obtained in pre-contracted tracheal smooth muscle in the presence of three concentrations of aqueous-ethanolic extract, propranolol and saline. Values of EC50 (the effecti...

The stimulatory effect of the extract of Portulaca oleracea (P. olerace) on β-adrenoceptor of tracheal smooth muscle was examined. To examine β-adrenoceptor stimulatory effect, concentration response curve to isoprenaline was obtained in pre-contracted tracheal smooth muscle in the presence of three concentrations of aqueous-ethanolic extract, propranolol and saline. Values of EC50 (the effecti...

Journal: :medical journal of islamic republic of iran 0
h sadraeisadraei from the department of pharmacology, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, i.r. iran. v hajhashemi a ghannadi m mohseni

teucrium polium l. (lamiaceae) is used in the traditional medicine of iran for the treatment of disorders of the gastrointestinal tract. the essential oil from the aerial parts of t polium was assessed for antispasmodic activity and compared with the effect of atropine and dicyclomine. acetylcholine and kc i were used for induction of contraction on rat isolated ileum. teucrium polium essential...

Journal: :iranian biomedical journal 0
سید محمد تقی منصوری seyed mohammad-taghi mansouri رضا شفیعی نیک reza shafiee-nick حیدر پارسایی heydar parsaee سید محمد سیدی seyed mohammad seyedi محمدرضا صابری mohammad-reza saberi حمید صادقیان hamid sadeghian

background: selective phosphodiesterase (pde3) inhibitors improve cardiac contractility and may use in congestive heart failure. however, their proarrhythmic potential is the most important side effect. methods: in this research, we evaluated the potential cardiotonic activity of six new synthesized selective pde3 inhibitors (6-hydroxy-4-methylquinolin-2(1h)-one derivatives) using the spontaneo...

Journal: :Journal of Ayub Medical College, Abbottabad : JAMC 2013
Asma Shaukat Naila Abrar Ayesha Naureen Muhammad Nawaz

BACKGROUND The use of beta blockers is limited by their ability to produce bronchospasm in asthmatics. Third generation beta-blockers like Nebivolol may show better tolerability because they may augment the release of nitric oxide (NO) from endothelial cells. However the involvement of NO in the respiratory effect of Nebivolol remains controversial. The present study, carried out on isolated tr...

Journal: :The Journal of pharmacology and experimental therapeutics 2005
Frederick J Ehlert

The theoretical basis for analyzing the effects of an allosteric modulator on the response to an agonist is described. The effects of an allosteric modulator on the concentration-response curve to an agonist can be attributed to changes in the observed dissociation constant and intrinsic efficacy of the agonist-receptor complex. Each of these two changes can be represented by a coefficient or f...

Journal: :Indian journal of experimental biology 2004
Shrinivas K Kulkarni Chandrashekhar S Patil Naveen K Jain Amarjit Singh

Biliary, ureteric and intestinal colic are extremely common clinical conditions associated with smooth muscle spasm. In the present study, antispasmodic activity was carried out against acetylcholine (10-640 ng/ml)-induced contractions on guinea pig ileum. Acetylcholine (10-640 ng/ml) induced concentration-dependent contraction of smooth muscle. Diclofenac, in varying concentration (9.4 x 10(-5...

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